LGR4 explained

Leucine-rich repeat-containing G-protein coupled receptor 4 is a protein that in humans is encoded by the LGR4 gene.^{[1] [2]} LGR4 is known to have a role in the development of the male reproductive tract, eyelids, hair and bone.

Mutations in this gene have been associated to osteoporosis (doi:10.1038/nature12124).

Further reading

• Hsu SY, Liang SG, Hsueh AJ . Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region . Mol. Endocrinol. . 12 . 12 . 1830–45 . 1999 . 9849958 . 10.1210/me.12.12.1830 . free .
• Loh ED, Broussard SR, Kolakowski LF . Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor . Biochem. Biophys. Res. Commun. . 282 . 3 . 757–64 . 2001 . 11401528 . 10.1006/bbrc.2001.4625 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .

Notes and References

1. Loh ED, Broussard SR, Liu Q, Copeland NG, Gilbert DJ, Jenkins NA, ((Kolakowski LF Jr)) . Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping . Cytogenet Cell Genet . 89 . 1–2 . 2–5 . Aug 2000 . 10894923 . 10.1159/000015576 . 607389 .
2. Web site: Entrez Gene: LGR4 leucine-rich repeat-containing G protein-coupled receptor 4.