LGALS3BP explained
Galectin-3-binding protein is a protein that in humans is encoded by the LGALS3BP gene.[1] [2] [3] [4]
Function
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell–cell and cell–matrix interactions. Using fluorescence in–situ hybridization, the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds to galectin 1.[4]
Clinical significance
LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity.[4]
Interactions
LGALS3BP has been shown to interact with LGALS3.[3] [5] [6]
Further reading
- Grassadonia A, Tinari N, Iurisci I, etal . 90K (Mac-2 BP) and galectins in tumor progression and metastasis. . Glycoconj. J. . 19 . 7–9 . 551–6 . 2004 . 14758079 . 10.1023/B:GLYC.0000014085.00706.d4 . 8981436 .
- Rosenberg I, Cherayil BJ, Isselbacher KJ, Pillai S . Mac-2-binding glycoproteins. Putative ligands for a cytosolic beta-galactoside lectin. . J. Biol. Chem. . 266 . 28 . 18731–6 . 1991 . 10.1016/S0021-9258(18)55124-3 . 1917996 . free .
- Yu B, Wright SD . LPS-dependent interaction of Mac-2-binding protein with immobilized CD14. . J. Inflamm. . 45 . 2 . 115–25 . 1995 . 7583357 .
- Koths K, Taylor E, Halenbeck R, etal . Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain. . J. Biol. Chem. . 268 . 19 . 14245–9 . 1993 . 10.1016/S0021-9258(19)85233-X . 8390986 . free .
- Inohara H, Akahani S, Koths K, Raz A . Interactions between galectin-3 and Mac-2-binding protein mediate cell-cell adhesion. . Cancer Res. . 56 . 19 . 4530–4 . 1996 . 8813152 .
- Brakebusch C, Jallal B, Fusco O, etal . Expression of the 90K immunostimulator gene is controlled by a promoter with unique features. . J. Biol. Chem. . 272 . 6 . 3674–82 . 1997 . 9013622 . 10.1074/jbc.272.6.3674 . free .
- Fusco O, Querzoli P, Nenci I, etal . 90K (MAC-2 BP) gene expression in breast cancer and evidence for the production of 90K by peripheral-blood mononuclear cells. . Int. J. Cancer . 79 . 1 . 23–6 . 1998 . 9495353 . 10.1002/(SICI)1097-0215(19980220)79:1<23::AID-IJC5>3.0.CO;2-Y . free .
- Sasaki T, Brakebusch C, Engel J, Timpl R . Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin. . EMBO J. . 17 . 6 . 1606–13 . 1998 . 9501082 . 10.1093/emboj/17.6.1606 . 1170508 .
- Trahey M, Weissman IL . Cyclophilin C-associated protein: a normal secreted glycoprotein that down-modulates endotoxin and proinflammatory responses in vivo. . Proc. Natl. Acad. Sci. U.S.A. . 96 . 6 . 3006–11 . 1999 . 10077627 . 10.1073/pnas.96.6.3006 . 15885 . 1999PNAS...96.3006T . free .
- Tinari N, Kuwabara I, Huflejt ME, etal . Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation. . Int. J. Cancer . 91 . 2 . 167–72 . 2001 . 11146440 . 10.1002/1097-0215(200002)9999:9999<::AID-IJC1022>3.3.CO;2-Q .
- Hellstern S, Sasaki T, Fauser C, etal . Functional studies on recombinant domains of Mac-2-binding protein. . J. Biol. Chem. . 277 . 18 . 15690–6 . 2002 . 11867635 . 10.1074/jbc.M200386200 . free .
- Marchetti A, Tinari N, Buttitta F, etal . Expression of 90K (Mac-2 BP) correlates with distant metastasis and predicts survival in stage I non-small cell lung cancer patients. . Cancer Res. . 62 . 9 . 2535–9 . 2002 . 11980646 .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Zhang H, Li XJ, Martin DB, Aebersold R . Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. . Nat. Biotechnol. . 21 . 6 . 660–6 . 2003 . 12754519 . 10.1038/nbt827 . 581283 .
- Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
- Bouwmeester T, Bauch A, Ruffner H, etal . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
- Kristiansen TZ, Bunkenborg J, Gronborg M, etal . A proteomic analysis of human bile. . Mol. Cell. Proteomics . 3 . 7 . 715–28 . 2005 . 15084671 . 10.1074/mcp.M400015-MCP200 . free .
Notes and References
- Calabrese G, Sures I, Pompetti F, Natoli G, Palka G, Iacobelli S . The gene (LGALS3BP) encoding the serum protein 90K, associated with cancer and infection by the human immunodeficiency virus, maps at 17q25 . Cytogenet Cell Genet . 69 . 3–4 . 223–5 . May 1995 . 7698018 . 10.1159/000133969 .
- Ullrich A, Sures I, D'Egidio M, Jallal B, Powell TJ, Herbst R, Dreps A, Azam M, Rubinstein M, Natoli C . The secreted tumor-associated antigen 90K is a potent immune stimulator . J Biol Chem . 269 . 28 . 18401–7 . Aug 1994 . 10.1016/S0021-9258(17)32322-0 . 8034587 . etal. free .
- Koths K, Taylor E, Halenbeck R, Casipit C, Wang A . Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain . J. Biol. Chem. . 268 . 19 . 14245–9 . July 1993 . 10.1016/S0021-9258(19)85233-X . 8390986 . free .
- Web site: Entrez Gene: LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein.
- Rosenberg I, Cherayil BJ, Isselbacher KJ, Pillai S . Mac-2-binding glycoproteins. Putative ligands for a cytosolic beta-galactoside lectin . J. Biol. Chem. . 266 . 28 . 18731–6 . October 1991 . 10.1016/S0021-9258(18)55124-3 . 1917996 . free .
- Tinari N, Kuwabara I, Huflejt ME, Shen PF, Iacobelli S, Liu FT. Fu-Tong Liu . Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation . Int. J. Cancer . 91 . 2 . 167–72 . January 2001 . 11146440 . 10.1002/1097-0215(200002)9999:9999<::AID-IJC1022>3.3.CO;2-Q .