LCTL explained

Lactase-like is a protein that in humans is encoded by the LCTL gene.^[1] Lactase-like is a glycosidase enzyme.

Function

This gene encodes a member of family 1 glycosidases. Glycosidases are enzymes that hydrolyze glycosidic bonds and are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved glutamic acid residues, which are required for enzymatic activity. The mouse ortholog of this protein has been characterized and has a domain structure of an N-terminal signal peptide, glycosidase domain, transmembrane domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Further reading

• Kim J, Eskiocak U, Stadler G, Lou Z, Kuro-o M, Shay JW, Wright WE . Short hairpin RNA screen indicates that Klotho beta/FGF19 protein overcomes stasis in human colonic epithelial cells . The Journal of Biological Chemistry . 286 . 50 . 43294–300 . December 2011 . 22020932 . 3234855 . 10.1074/jbc.M111.267641 . free .
• Mian IS . Sequence, structural, functional, and phylogenetic analyses of three glycosidase families . Blood Cells, Molecules & Diseases . 24 . 2 . 83–100 . June 1998 . 9779294 . 10.1006/bcmd.1998.9998 .
• Ito S, Fujimori T, Hayashizaki Y, Nabeshima Y . Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1576 . 3 . 341–5 . July 2002 . 12084582 . 10.1016/S0167-4781(02)00281-6 .

Notes and References

1. Web site: Entrez Gene: Lactase-like. 2013-09-25 .