LCOR explained

Ligand-dependent corepressor is a protein that in humans is encoded by the LCOR gene.^{[1] [2] [3]}

Function

LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box.^[3]

Further reading

• Nagase T, Nakayama M, Nakajima D, etal . Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 8 . 2 . 85–95 . 2001 . 11347906 . 10.1093/dnares/8.2.85 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Kunieda T, Park JM, Takeuchi H, Kubo T . Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain(1). . FEBS Lett. . 535 . 1–3 . 61–5 . 2003 . 12560079 . 10.1016/S0014-5793(02)03858-9 . 83745027 .
• Shi Y, Sawada J, Sui G, etal . Coordinated histone modifications mediated by a CtBP co-repressor complex . Nature . 422 . 6933 . 735–8 . 2003 . 12700765 . 10.1038/nature01550 . 2003Natur.422..735S . 2670859 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Deloukas P, Earthrowl ME, Grafham DV, etal . The DNA sequence and comparative analysis of human chromosome 10 . Nature . 429 . 6990 . 375–81 . 2004 . 15164054 . 10.1038/nature02462 . 2004Natur.429..375D . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Ligand-dependent corepressor

Notes and References

1. Fernandes I, Bastien Y, Wai T, Nygard K, Lin R, Cormier O, Lee HS, Eng F, Bertos NR, Pelletier N, Mader S, Han VK, Yang XJ, White JH . Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms . Mol Cell . 11 . 1 . 139–50 . Jan 2003 . 12535528 . 10.1016/S1097-2765(03)00014-5 . free .
2. White JH, Fernandes I, Mader S, Yang XJ . Corepressor recruitment by agonist-bound nuclear receptors . Vitam Horm . Vitamins & Hormones . 68 . 123–43 . Jun 2004 . 15193453 . 10.1016/S0083-6729(04)68004-6 . 978-0-12-709868-5 .
3. Web site: Entrez Gene: LCOR ligand dependent nuclear receptor corepressor.