LCMT2 explained

Leucine carboxyl methyltransferase 2 is an enzyme that in humans is encoded by the LCMT2 gene.^{[1] [2] [3]}

The protein encoded by this intronless gene belongs to the methyltransferase superfamily and acts as a G₁/S and G₂/M phase checkpoint regulator. It has been hypothesized that cigarette smoke-induced oxidative stress and transforming growth factor beta 1 may inhibit cellular proliferation by modulating the expression of this protein.

Further reading

• De Baere I, Derua R, Janssens V, etal . Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue . Biochemistry . 38 . 50 . 16539–47 . 2000 . 10600115 . 10.1021/bi991646a .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Marwick JA, Kirkham P, Gilmour PS, etal . Cigarette smoke-induced oxidative stress and TGF-beta1 increase p21waf1/cip1 expression in alveolar epithelial cells . Ann. N. Y. Acad. Sci. . 973 . 278–83 . 2003 . 12485877 . 10.1111/j.1749-6632.2002.tb04649.x . 84732926 .
• Ng CC, Arakawa H, Fukuda S, etal . p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1 . Oncogene . 22 . 28 . 4449–58 . 2003 . 12853982 . 10.1038/sj.onc.1206586 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Kawamata N, Inagaki N, Mizumura S, etal . Methylation status analysis of cell cycle regulatory genes (p16INK4A, p15INK4B, p21Waf1/Cip1, p27Kip1 and p73) in natural killer cell disorders . Eur. J. Haematol. . 74 . 5 . 424–9 . 2005 . 15813917 . 10.1111/j.1600-0609.2005.00417.x . 46197026 .
• Noma A, Kirino Y, Ikeuchi Y, Suzuki T . Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA . EMBO J. . 25 . 10 . 2142–54 . 2006 . 16642040 . 10.1038/sj.emboj.7601105 . 1462984 .
• Liu FY, Qi JP, Xu FL, Wu AP . Clinicopathological and immunohistochemical analysis of gastrointestinal stromal tumor . World J. Gastroenterol. . 12 . 26 . 4161–5 . 2006 . 10.3748/wjg.v12.i26.4161 . 16830365 . 4087364 . free .
• Moon SK, Choi YH, Kim CH, Choi WS . p38MAPK mediates benzyl isothiocyanate-induced p21WAF1 expression in vascular smooth muscle cells via the regulation of Sp1 . Biochem. Biophys. Res. Commun. . 350 . 3 . 662–8 . 2006 . 17026958 . 10.1016/j.bbrc.2006.09.092 .

Notes and References

1. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res . 5 . 1 . 31–9 . Aug 1998 . 9628581 . 10.1093/dnares/5.1.31 . free .
2. Noma A, Suzuki T . Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis . Nucleic Acids Symp Ser (Oxf) . 50. 50 . 65–6 . Dec 2006 . 17150819 . 10.1093/nass/nrl032 .
3. Web site: Entrez Gene: LCMT2 leucine carboxyl methyltransferase 2.