LBX1 explained

Transcription factor LBX1 is a protein that in humans is encoded by the LBX1 gene.^{[1] [2]}

This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes.

In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles.

Further reading

• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Deloukas P, Earthrowl ME, Grafham DV, etal . The DNA sequence and comparative analysis of human chromosome 10. . Nature . 429 . 6990 . 375–81 . 2004 . 15164054 . 10.1038/nature02462 . 2004Natur.429..375D . free .
• de Mollerat XJ, Gurrieri F, Morgan CT, etal . A genomic rearrangement resulting in a tandem duplication is associated with split hand-split foot malformation 3 (SHFM3) at 10q24. . Hum. Mol. Genet. . 12 . 16 . 1959–71 . 2004 . 12913067 . 10.1093/hmg/ddg212 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Kozmik Z, Holland LZ, Schubert M, etal . Characterization of Amphioxus AmphiVent, an evolutionarily conserved marker for chordate ventral mesoderm. . Genesis . 29 . 4 . 172–9 . 2001 . 11309850 . 10.1002/gene.1021 . 7730828 .
• Moretti P, Simmons P, Thomas P, etal . Identification of homeobox genes expressed in human haemopoietic progenitor cells. . Gene . 144 . 2 . 213–9 . 1994 . 7518789 . 10.1016/0378-1119(94)90380-8 .

Notes and References

1. Jagla K, Dolle P, Mattei MG, Jagla T, Schuhbaur B, Dretzen G, Bellard F, Bellard M . Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes . Mech Dev . 53 . 3 . 345–56 . Jul 1996 . 8645601 . 10.1016/0925-4773(95)00450-5 . 19021832 . free .
2. Web site: Entrez Gene: LBX1 ladybird homeobox 1.