LAT2 explained

Linker for activation of T-cells family member 2 is a protein that in humans is encoded by the LAT2 gene.^{[1] [2] [3]}

This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein.^[3]

Further reading

• Rivera J . NTAL/LAB and LAT: a balancing act in mast-cell activation and function . Trends Immunol. . 26 . 3 . 119–22 . 2005 . 15745852 . 10.1016/j.it.2005.01.001 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Pérez Jurado LA . Molecular definition of the chromosome 7 deletion in Williams syndrome and parent-of-origin effects on growth . Am. J. Hum. Genet. . 59 . 4 . 781–92 . 1996 . 8808592 . 1914804 . vanc. Peoples R . Kaplan P . 3 . Hamel . BC . Francke . U .
• Suzuki Y . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . vanc. Yoshitomo-Nakagawa K . Maruyama K . 3 . Suyama . A . Sugano . S .
• Martindale DW . Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23 . Mamm. Genome . 11 . 10 . 890–8 . 2000 . 11003705 . 10.1007/s003350010166 . vanc. Wilson MD . Wang D . 3 . Burke . Robert D. . Chen . Xianming . Duronio . Vincent . Koop . Ben F. . 8575994 .
• Zhang QH . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells . Genome Res. . 10 . 10 . 1546–60 . 2001 . 11042152 . 10.1101/gr.140200 . 310934 . vanc. Ye M . Wu XY . 3 . Ren . SX . Zhao . M . Zhao . CJ . Fu . G . Shen . Y . Fan . HY .
• Doyle JL, DeSilva U, Miller W, Green ED . Divergent human and mouse orthologs of a novel gene (WBSCR15/Wbscr15) reside within the genomic interval commonly deleted in Williams syndrome . Cytogenet. Cell Genet. . 90 . 3–4 . 285–90 . 2001 . 11124535 . 10.1159/000056790 . 34058309 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Brdicka T . Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling . J. Exp. Med. . 196 . 12 . 1617–26 . 2003 . 12486104 . 10.1084/jem.20021405 . 2196071 . vanc. Imrich M . Angelisová P . 3 . Brdickova . N. . Horvath . O. . Spicka . J. . Hilgert . I. . Luskova . P. . Draber . P. .
• Hillier LW . The DNA sequence of human chromosome 7 . Nature . 424 . 6945 . 157–64 . 2003 . 12853948 . 10.1038/nature01782 . vanc. Fulton RS . Fulton LA . 3 . Graves . Tina A. . Pepin . Kymberlie H. . Wagner-Mcpherson . Caryn . Layman . Dan . Maas . Jason . Jaeger . Sara . 2003Natur.424..157H . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Koonpaew S, Janssen E, Zhu M, Zhang W . The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB . J. Biol. Chem. . 279 . 12 . 11229–35 . 2004 . 14722116 . 10.1074/jbc.M311394200 . free .
• Tkaczyk C . NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation . Blood . 104 . 1 . 207–14 . 2004 . 15010370 . 10.1182/blood-2003-08-2769 . vanc. Horejsi V . Iwaki S . 3 . Draber . P . Samelson . LE . Satterthwaite . AB . Nahm . DH . Metcalfe . DD . Gilfillan . AM . free .
• Janssen E, Zhu M, Craven B, Zhang W . Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding . J. Immunol. . 172 . 11 . 6810–9 . 2004 . 15153499 . 10.4049/jimmunol.172.11.6810. free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Tedoldi S . Transmembrane adaptor molecules: a new category of lymphoid-cell markers . Blood . 107 . 1 . 213–21 . 2006 . 16160011 . 10.1182/blood-2005-06-2273 . vanc. Paterson JC . Hansmann ML . 3 . Natkunam . Y . Rüdiger . T . Angelisova . P . Du . MQ . Roberton . H . Roncador . G . 340034 . free .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . vanc. Venkatesan K . Hao T . 3 . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Osborne LR, Martindale D, Scherer SW, Shi XM, Huizenga J, Heng HH, Costa T, Pober B, Lew L, Brinkman J, Rommens J, Koop B, Tsui LC . Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients . Genomics . 36 . 2 . 328–36 . Jan 1997 . 8812460 . 10.1006/geno.1996.0469 . free .
2. Janssen E, Zhu M, Zhang W, Koonpaew S, Zhang W . LAB: a new membrane-associated adaptor molecule in B cell activation . Nat Immunol . 4 . 2 . 117–23 . Jan 2003 . 12514734 . 10.1038/ni882 . 23727758 .
3. Web site: Entrez Gene: LAT2 linker for activation of T cells family, member 2.