LARS2 explained

Probable leucyl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the LARS2 gene.^{[1] [2]}

This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid.^[3]

Further reading

• Olsson P, Wennberg AL . [Midwife and research. Conference report] . Jordemodern . 104 . 11 . 408–9, 404 . 1992 . 1684970 .
• Nomura N, Miyajima N, Sazuka T, etal . Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. . DNA Res. . 1 . 1 . 27–35 . 1995 . 7584026 . 10.1093/dnares/1.1.27 . free .
• Nomura N, Miyajima N, Sazuka T, etal . Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). . DNA Res. . 1 . 1 . 47–56 . 1995 . 7584028 . 10.1093/dnares/1.1.47 . free .
• Szeles A, Yang Y, Sandlund AM, etal . Human/mouse microcell hybrid based elimination test reduces the putative tumor suppressor region at 3p21.3 to 1.6 cM. . Genes Chromosomes Cancer . 20 . 4 . 329–36 . 1998 . 9408748 . 10.1002/(SICI)1098-2264(199712)20:4<329::AID-GCC3>3.0.CO;2-3 . 39132097 .
• Kiss H, Kedra D, Yang Y, etal . A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3. . Hum. Genet. . 105 . 6 . 552–9 . 2000 . 10647888 . 10.1007/s004399900188 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Yao YN, Wang L, Wu XF, Wang ED . The processing of human mitochondrial leucyl-tRNA synthetase in the insect cells. . FEBS Lett. . 534 . 1–3 . 139–42 . 2004 . 12527375 . 10.1016/S0014-5793(02)03833-4 . 21901003 . free .
• Park H, Davidson E, King MP . The pathogenic A3243G mutation in human mitochondrial tRNALeu(UUR) decreases the efficiency of aminoacylation . Biochemistry . 42 . 4 . 958–64 . 2003 . 12549915 . 10.1021/bi026882r .
• Yao YN, Wang L, Wu XF, Wang ED . Human mitochondrial leucyl-tRNA synthetase with high activity produced from Escherichia coli . Protein Expr. Purif. . 30 . 1 . 112–6 . 2004 . 12821328 . 10.1016/S1046-5928(03)00097-4 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Munakata K, Iwamoto K, Bundo M, Kato T . Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia . Biol. Psychiatry . 57 . 5 . 525–32 . 2005 . 15737668 . 10.1016/j.biopsych.2004.11.041 . 28499960 .
• 't Hart LM, Hansen T, Rietveld I, etal . Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene . Diabetes . 54 . 6 . 1892–5 . 2005 . 15919814 . 10.2337/diabetes.54.6.1892 . free . 1765/10387 . free .

Notes and References

1. Sohm B, Sissler M, Park H, King MP, Florentz C . Recognition of human mitochondrial tRNALeu(UUR) by its cognate leucyl-tRNA synthetase . J Mol Biol . 339 . 1 . 17–29 . May 2004 . 15123417 . 10.1016/j.jmb.2004.03.066 .
2. Web site: Entrez Gene: LARS2 leucyl-tRNA synthetase 2, mitochondrial.
3. Web site: Entrez Gene: LARS2 leucyl-tRNA synthetase 2, mitochondrial.