HBXIP explained

Hepatitis B virus X-interacting protein is a protein that in humans is encoded by the HBXIP gene.^{[1] [2]}

This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus.

Interactions

HBXIP has been shown to interact with NCOA6.^[3]

Further reading

• Shamay M, Barak O, Doitsh G, Ben-Dor I, Shaul Y . Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription . The Journal of Biological Chemistry . 277 . 12 . 9982–8 . March 2002 . 11788598 . 10.1074/jbc.M111354200 . free .
• Li Y, Lu YY . Applying a highly specific and reproducible cDNA RDA method to clone garlic up-regulated genes in human gastric cancer cells . World Journal of Gastroenterology . 8 . 2 . 213–6 . April 2002 . 11925594 . 4658353 . 10.3748/wjg.v8.i2.213 . free .
• Marusawa H, Matsuzawa S, Welsh K, Zou H, Armstrong R, Tamm I, Reed JC . HBXIP functions as a cofactor of survivin in apoptosis suppression . The EMBO Journal . 22 . 11 . 2729–40 . June 2003 . 12773388 . 156760 . 10.1093/emboj/cdg263 .
• Kong HJ, Park MJ, Hong S, Yu HJ, Lee YC, Choi YH, Cheong J . Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2 . Hepatology . 38 . 5 . 1258–66 . November 2003 . 14578865 . 10.1053/jhep.2003.50451 . free .
• Lee SH, Park SG, Lim SO, Jung G . The hepatitis B virus X protein up-regulates lymphotoxin alpha expression in hepatocytes . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease . 1741 . 1–2 . 75–84 . June 2005 . 15955450 . 10.1016/j.bbadis.2004.10.004 . free .
• Lee AT, Ren J, Wong ET, Ban KH, Lee LA, Lee CG . The hepatitis B virus X protein sensitizes HepG2 cells to UV light-induced DNA damage . The Journal of Biological Chemistry . 280 . 39 . 33525–35 . September 2005 . 16055925 . 10.1074/jbc.M506628200 . free .
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . September 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
• Minczuk M, Mroczek S, Pawlak SD, Stepien PP . Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP . The FEBS Journal . 272 . 19 . 5008–19 . October 2005 . 16176273 . 10.1111/j.1742-4658.2005.04910.x . 40846992 . free .
• Muroyama R, Kato N, Yoshida H, Otsuka M, Moriyama M, Wang Y, Shao RX, Dharel N, Tanaka Y, Ohta M, Tateishi R, Shiina S, Tatsukawa M, Fukai K, Imazeki F, Yokosuka O, Shiratori Y, Omata M . Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma . Journal of Hepatology . 45 . 6 . 805–12 . December 2006 . 17050029 . 10.1016/j.jhep.2006.07.025 .
• Chen J, Siddiqui A . Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress . Journal of Virology . 81 . 12 . 6757–60 . June 2007 . 17428866 . 1900104 . 10.1128/JVI.00172-07 .

Notes and References

1. Melegari M, Scaglioni PP, Wands JR . Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication . Journal of Virology . 72 . 3 . 1737–43 . March 1998 . 9499022 . 109461 . 10.1128/jvi.72.3.1737-1743.1998.
2. Web site: Entrez Gene: HBXIP hepatitis B virus x interacting protein.
3. Kong HJ, Park MJ, Hong S, Yu HJ, Lee YC, Choi YH, Cheong J . Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2 . Hepatology . 38 . 5 . 1258–66 . November 2003 . 14578865 . 10.1053/jhep.2003.50451 . free .