Late endosomal/lysosomal adaptor, mapk and mtor activator 1 explained

Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 is a protein that in humans is encoded by the LAMTOR1 gene.^[1]

Further reading

• Nada S, Hondo A, Kasai A, Koike M, Saito K, Uchiyama Y, Okada M . The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes . EMBO J. . 28 . 5 . 477–89 . March 2009 . 19177150 . 2657578 . 10.1038/emboj.2008.308 .
• Hoshino D, Tomari T, Nagano M, Koshikawa N, Seiki M . A novel protein associated with membrane-type 1 matrix metalloproteinase binds p27(kip1) and regulates RhoA activation, actin remodeling, and matrigel invasion . J. Biol. Chem. . 284 . 40 . 27315–26 . October 2009 . 19654316 . 2785659 . 10.1074/jbc.M109.041400 . free .
• Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM . Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids . Cell . 141 . 2 . 290–303 . April 2010 . 20381137 . 3024592 . 10.1016/j.cell.2010.02.024 .
• Hoshino D, Koshikawa N, Seiki M . A p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC . J. Biol. Chem. . 286 . 4 . 3139–48 . January 2011 . 21087931 . 3024806 . 10.1074/jbc.M110.159715 . free .
• Malek M, Guillaumot P, Huber AL, Lebeau J, Pétrilli V, Kfoury A, Mikaelian I, Renno T, Manié SN . LAMTOR1 depletion induces p53-dependent apoptosis via aberrant lysosomal activation . Cell Death Dis . 3 . 4. e300 . April 2012 . 22513874 . 3358017 . 10.1038/cddis.2012.39 .
• Zada S, Noh HS, Baek SM, Ha JH, Hahm JR, Kim DR . Depletion of p18/LAMTOR1 promotes cell survival via activation of p27(kip1) -dependent autophagy under starvation . Cell Biol. Int. . 39 . 11 . 1242–50 . November 2015 . 26032166 . 10.1002/cbin.10497 . 25267133 .
• Wang L, Skotland T, Berge V, Sandvig K, Llorente A . Exosomal proteins as prostate cancer biomarkers in urine: From mass spectrometry discovery to immunoassay-based validation . Eur J Pharm Sci . 98 . 80–85 . February 2017 . 27664330 . 10.1016/j.ejps.2016.09.023 . 28505134 .
• Li X, Gao M, Choi JM, Kim BJ, Zhou MT, Chen Z, Jain AN, Jung SY, Yuan J, Wang W, Wang Y, Chen J . Clustered, Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-coupled Affinity Purification/Mass Spectrometry Analysis Revealed a Novel Role of Neurofibromin in mTOR Signaling . Mol. Cell. Proteomics . 16 . 4 . 594–607 . April 2017 . 28174230 . 5383781 . 10.1074/mcp.M116.064543 . free .
• ((de Araujo MEG)), Naschberger A, Fürnrohr BG, Stasyk T, Dunzendorfer-Matt T, Lechner S, Welti S, Kremser L, Shivalingaiah G, Offterdinger M, Lindner HH, Huber LA, Scheffzek K . Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling . Science . 358 . 6361 . 377–381 . October 2017 . 28935770 . 10.1126/science.aao1583 . 2017Sci...358..377D . 206662367 .

Notes and References

1. Web site: Entrez Gene: Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. 2018-10-01.