LAIR2 explained

Leukocyte-associated immunoglobulin-like receptor 2 is a protein that in humans is encoded by the LAIR2 gene.^{[1] [2]}

The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily, including LAIR1. The function of this protein is unknown, although it is thought to be secreted and may help modulate mucosal tolerance. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Lebbink RJ . The soluble leukocyte-associated Ig-like receptor (LAIR)-2 antagonizes the collagen/LAIR-1 inhibitory immune interaction . J. Immunol. . 180 . 3 . 1662–9 . 2008 . 18209062 . 10.4049/jimmunol.180.3.1662. van den Berg MC . de Ruiter T . Raynal . N . Van Roon . JA . Lenting . PJ . Jin . B . Meyaard . L . free .
• Denoeud F . Prominent use of distal 5′ transcription start sites and discovery of a large number of additional exons in ENCODE regions . Genome Res. . 17 . 6 . 746–59 . 2007 . 17567994 . 10.1101/gr.5660607 . 1891335 . Kapranov P . Ucla C . Frankish . A. . Castelo . R. . Drenkow . J. . Lagarde . J. . Alioto . T. . Manzano . C. .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Wende H, Volz A, Ziegler A . Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster . Immunogenetics . 51 . 8–9 . 703–13 . 2000 . 10941842 . 10.1007/s002510000187 . 20719684 .
• Meyaard L . Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells . J. Immunol. . 162 . 10 . 5800–4 . 1999 . 10229813 . Hurenkamp J . Clevers H . Lanier . LL . Phillips . JH . 10.4049/jimmunol.162.10.5800 .
• Hillier LD . Generation and analysis of 280,000 human expressed sequence tags . Genome Res. . 6 . 9 . 807–28 . 1997 . 8889549 . 10.1101/gr.6.9.807 . Lennon G . Becker M . Bonaldo . M F . Chiapelli . B . Chissoe . S . Dietrich . N . Dubuque . T . Favello . A . free .

Notes and References

1. Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH . Grant Robert Sutherland . LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes . Immunity . 7 . 2 . 283–90 . Sep 1997 . 9285412 . 10.1016/S1074-7613(00)80530-0 . free . 2066/26173 . free .
2. Web site: Entrez Gene: LAIR2 leukocyte-associated immunoglobulin-like receptor 2.