L3MBTL explained

Lethal(3)malignant brain tumor-like protein is a protein that in humans is encoded by the L3MBTL gene.^{[1] [2] [3]}

This gene encodes the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion mother cells in the optic centers of the brain. This gene product is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

Further reading

• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• MacGrogan D, Kalakonda N, Alvarez S, etal . Structural integrity and expression of the L3MBTL gene in normal and malignant hematopoietic cells . Genes Chromosomes Cancer . 41 . 3 . 203–13 . 2004 . 15334543 . 10.1002/gcc.20087 . 35563365 .
• Li J, Bench AJ, Vassiliou GS, etal . Imprinting of the human L3MBTL gene, a polycomb family member located in a region of chromosome 20 deleted in human myeloid malignancies . Proc. Natl. Acad. Sci. U.S.A. . 101 . 19 . 7341–6 . 2004 . 15123827 . 10.1073/pnas.0308195101 . 409920 . 2004PNAS..101.7341L . free .
• Wang WK, Tereshko V, Boccuni P, etal . Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets . Structure . 11 . 7 . 775–89 . 2004 . 12842041 . 4693639 . 10.1016/S0969-2126(03)00127-8 .
• Boccuni P, MacGrogan D, Scandura JM, Nimer SD . The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6) . J. Biol. Chem. . 278 . 17 . 15412–20 . 2003 . 12588862 . 10.1074/jbc.M300592200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Deloukas P, Matthews LH, Ashurst J, etal . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . free .
• Fossey SC, Mychaleckyj JC, Pendleton JK, etal . A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20 . Genomics . 76 . 1–3 . 45–57 . 2001 . 11549316 . 10.1006/geno.2001.6584 .
• Dias Neto E, Correa RG, Verjovski-Almeida S, etal . Shotgun sequencing of the human transcriptome with ORF expressed sequence tags . Proc. Natl. Acad. Sci. U.S.A. . 97 . 7 . 3491–6 . 2000 . 10737800 . 10.1073/pnas.97.7.3491 . 16267 . 2000PNAS...97.3491D . free .
• Ishikawa K, Nagase T, Suyama M, etal . Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res. . 5 . 3 . 169–76 . 1998 . 9734811 . 10.1093/dnares/5.3.169 . free .

Notes and References

1. Koga H, Matsui S, Hirota T, Takebayashi S, Okumura K, Saya H . A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes . Oncogene . 18 . 26 . 3799–809 . Sep 1999 . 10445843 . 10.1038/sj.onc.1202732 . 8186230 .
2. Trojer P, Li G, ((Sims RJ III)), Vaquero A, Kalakonda N, Boccuni P, Lee D, Erdjument-Bromage H, Tempst P, Nimer SD, Wang YH, Reinberg D . L3MBTL1, a histone-methylation-dependent chromatin lock . Cell . 129 . 5 . 915–28 . Jun 2007 . 17540172 . 10.1016/j.cell.2007.03.048 . 16425537 . free .
3. Web site: Entrez Gene: L3MBTL l(3)mbt-like (Drosophila).