L1TD1 explained
LINE-1 type transposase domain containing 1, also known as L1TD1, is an RNA-binding protein that involved with self-renewal of undifferentiated human embryonic stem cells and cancer cell proliferation. L1TD1 has been reported to associate with the development of several cancers.[1] [2] [3] [4]
Further reading
- Mitsui K, Tokuzawa Y, Itoh H, etal . The homeoprotein Nanog isrequired for maintenance of pluripotency in mouse epiblast and ES cells . Cell . 113 . 5 . 631–42 . 2003 . 12787504 . 10.1016/S0092-8674(03)00393-3. 18836242 . free .
- Cash HL, Tao L, Yuan JM, etal . LINE-1 hypomethylation is associated with bladder cancer risk among nonsmoking Chinese . Int J Cancer . 130 . 5 . 1151–9 . 2012 . 21445976 . 10.1002/ijc.26098 . 3208798.
Notes and References
- Iwabuchi KA, Yamakawa T, Sato Y, Ichisaka T, Takahashi K, Okita K, Yamanaka S . ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC generation, but it is dispensable for the maintenance and induction of pluripotency . PLOS ONE . 6 . 5 . e20461 . May 2011 . 21637830 . 10.1371/journal.pone.0020461 . 3102727. 2011PLoSO...620461I . free .
- Närvä E, Rahkonen N, Emani MR, Lund R, Pursiheimo JP, Nästi J, Autio R, Rasool O, Denessiouk K, Lähdesmäki H, Rao A, Lahesmaa R . RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation . Stem Cells . 30 . 3 . 452–60 . March 2012 . 22162396 . 10.1002/stem.1013 . 3507993.
- Wong RC, Ibrahim A, Fong H, Thompson N, Lock LF, Donovan PJ . L1TD1 is a marker for undifferentiated human embryonic stem cells . PLOS ONE . 6 . 4 . e19355 . April 2011 . 21559406 . 10.1371/journal.pone.0019355 . 3084827. 2011PLoSO...619355W . free .
- Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y . LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis . Cancer Epidemiol Biomarkers Prev . 17 . 10 . 2555–64 . October 2008 . 18842996 . 10.1158/1055-9965.EPI-08-0112. 24719399 .