L. S. Shashidhara Explained
L. S. Shashidhara |
Birth Date: | 1963 3, df=y |
Birth Place: | Karnataka, India |
Nationality: | Indian |
Lingadahalli Subrahmanya Shashidhara (born 1963) is an Indian developmental biologist, geneticist and a professor of biology currently serving as the Centre Director of National Centre for Biological Sciences, Bengaluru, India. He is a Professor at the Indian Institute of Science Education and Research, Pune, and at Ashoka University, Sonepat, India. He heads the LSS Laboratory at IISER[1] and is known for his studies on Drosophila, particularly the evolution of appendages and functions of homeotic selector genes.[2] He is a J. C. Bose National Fellow of the Department of Science and Technology and an elected fellow of the Indian National Science Academy,[3] Indian Academy of Sciences[4] and the National Academy of Sciences, India.[5] The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 2008, for his contributions to biological sciences.[6]
In 2018, L.S. Shashidhara was elected an Associate Member of European Molecular Biology Organization (EMBO), making him the third scientist from India to join a group of about 1800 researchers.
L. S. Shashidhara was elected as the president of the International Union of Biological Sciences (IUBS) in the 33rd General Assembly of IUBS held during the Centenary Year Event of IUBS, at Oslo, in 2019. On behalf of IUBS, Shashidhara is steering an international project on Climate Change Education (titled as TROP ICSU). This project is supported by many unions and UN organizations.
Biography
L. S. Shashidhara, born on 23 March 1963 in the south Indian state of Karnataka, graduated in science from University of Agricultural Sciences, Dharwad (UAS) in 1985 and obtained a master's degree in Genetics and Plant breeding in 1987 from the same university.[7] After a brief stint (1987–88) at UAS as a teaching associate, he moved to University of Cambridge in 1988 for his doctoral studies to secure a PhD in 1991. On completion of his post-doctoral studies at Cambridge (1991–93), he returned to India to join National Centre for Biological Sciences and worked as a visiting fellow for two years. Subsequently, he moved to Centre for Cellular and Molecular Biology (CCMB) in 1995 as a scientist (group leader)[8] where he served until 2007 when he was transferred, on deputation, to the Pune centre of Indian Institutes of Science Education and Research (IISER) as a professor.[9] Since then, he has been serving the institute as a professor and has served as the chair of Biology and the coordinator of the department of biology.[10] He pursues his research interests as the head of the LSS Laboratory at IISER, where he hosts a number doctoral and postdoctoral scholars. He also serves as an honorary professor at Jawaharlal Nehru Centre for Advanced Scientific Research. He served as the vice-president of the Indian National Science Academy from 2015 to 2017 and secretary general of the International Union of Biological Sciences from 2015-2019.
Career
Shashidhara's research was focused on developmental biology, specifically the development of limbs and the role played by Ultrabithorax, a Hox gene, functioning as a transcription factor.[11] Studying Drosophila melanogaster (commonly known as fruit fly) as a model, he elucidated the molecular pathways Wnt, TGF-? and EGFR/Ras that impact growth control and developed a fly model for studying Adenomatous polyposis coli, the colon cancer gene in humans. His studies are reported to have assisted in a wider understanding of the relation between genes and diseases in humans and in the development of cancer drug discovery systems. His research findings have been published in a number of articles published in peer-reviewed journals,[12] several of them have been listed in online article repositories such as Metascience,[13] PubMed, and ResearchGate.[14] He has also published many general articles and has delivered keynote addresses and featured talks.[15] [16] He served as the secretary-general of the International Union of Biological Sciences (IUBS),[17] during 2015–2019 and is associated with the Journal of Genetics and Current Science as their associate editor and with Scientific Reports as a member of its editorial board.
Awards and honours
Shashidhara, a J. C. Bose National Fellow of the Department of Science and Technology, received the Technology Prize in Biological Sciences of the Council of Scientific and Industrial Research in 2003[18] and the Outstanding Research Investigator Award of the Science Research Council of the Department of Atomic Energy in 2006. The Indian academy of Sciences elected him as a fellow in 2007 and he became an elected fellow of the Indian National Science Academy and the National Academy of Sciences, India in 2008. The same year he received the Shanti Swarup Bhatnagar Prize of the Council of Scientific and Industrial Research, one of the highest Indian science awards, for his contributions to Biological Sciences. In 2018, L.S. Shashidhara has been elected an Associate Member of European Molecular Biology Organization (EMBO). He is currently elected as the president of International Union Of Biological Sciences.
Selected bibliography
Scientific articles
- Vaid . Pooja M. . Puntambekar . Anirudha K. . Jumle . Nutan S. . Banale . Rituja A. . Ansari . Danish . Reddy . Ruhi R. . Unde . Rohini R. . Namewar . Namrata P. . Kelkar . Devaki A. . Shashidhara . L. S. . Koppiker . Chaitanyanand B. . Kulkarni . Madhura D. . Evaluation of tumor-infiltrating lymphocytes (TILs) in molecular subtypes of an Indian cohort of breast cancer patients . Diagnostic Pathology . 21 November 2022 . 17 . 1 . 91 . 10.1186/s13000-022-01271-y . 36411483 . 9677664 . free .
- Mave . Vidya . Shaikh . Arsh . Monteiro . Joy Merwin . Bogam . Prasad . Pujari . Bhalchandra S. . Gupte . Nikhil . Association of national and regional lockdowns with COVID-19 infection rates in Pune, India . Scientific Reports . 21 June 2022 . 12 . 1 . 10446 . 10.1038/s41598-022-14674-0 . 35729206 . 9212203 . 2022NatSR..1210446M .
- Bogam . Prasad . Joshi . Aparna . Nagarkar . Sanket . Jain . Divyashri . Gupte . Nikhil . Shashidhara . Ls . Monteiro . Joy Merwin . Mave . Vidya . Burden of COVID-19 and case fatality rate in Pune, India: an analysis of the first and second wave of the pandemic . IJID Regions . March 2022 . 2 . 74–81 . 10.1016/j.ijregi.2021.12.006 . 35721428 . 8690685 . 235632750 .
- Rahman . Ayesha . Shashidhara . Lingadahalli S. . Analyzing the influence of IL18 in regulation of YAP1 in breast oncogenesis using cBioportal . Cancer Reports . March 2022 . 5 . 3 . e1484 . 10.1002/cnr2.1484 . 34196131 . 8955059 .
- Chakraborty . Anirban . Kumar . Sumit . Shashidhara . L. S. . Taneja . Anjali . Building Sustainable Societies through Purpose-Driven Universities: A Case Study from Ashoka University (India) . Sustainability . 2 July 2021 . 13 . 13 . 7423 . 10.3390/su13137423 . free .
- Busheri . Laleh . Dixit . Santosh . Nare . Smeeta . Alhat . Rashmi . Thomas . George . Jagtap . Mangal . Navgire . Ruth . Shinde . Priya . Banale . Rituja . Unde . Rohini . Reddy . Ruhi . Shaikh . Shahin . Konnur . Aishwarya . Namewar . Namrata . Bapat . Ashwini . Patil . Ankita . Johari . Rateeka . Kushwaha . Roli . Kumari . Wimpy . Varghese . Beenu . Deshpande . Pooja . Deshmukh . Chetan . Kelkar . Devaki A. . Shashidhara . L S . Koppiker . Chaitanyanand B . Kulkarni . Madhura . Breast cancer biobank from a single institutional cohort in an urban setting in india: Tumor characteristics and survival outcomes . Cancer Treatment and Research Communications . 2021 . 28 . 100409 . 10.1016/j.ctarc.2021.100409 . 34098400 . 235369714 . free .
- Paul . Rachel . Giraud . Guillaume . Domsch . Katrin . Duffraisse . Marilyne . Marmigère . Frédéric . Khan . Soumen . Vanderperre . Solene . Lohmann . Ingrid . Stoks . Robby . Shashidhara . L. S. . Merabet . Samir . Hox dosage contributes to flight appendage morphology in Drosophila . Nature Communications . 17 May 2021 . 12 . 1 . 2892 . 10.1038/s41467-021-23293-8 . 34001903 . 8129201 . 2021NatCo..12.2892P .
- Nagarkar . Sanket . Wasnik . Ruchi . Govada . Pravallika . Cohen . Stephen . Shashidhara . L S . Promoter Proximal Pausing Limits Tumorous Growth Induced by the Yki Transcription Factor in Drosophila . Genetics . September 2020 . 216 . 1 . 67–77 . 10.1534/genetics.120.303419 . 32737120 . 7463282 .
- Groth . Casper . Vaid . Pooja . Khatpe . Aditi . Prashali . Nelchi . Ahiya . Avantika . Andrejeva . Diana . Chakladar . Madhumita . Nagarkar . Sanket . Paul . Rachel . Kelkar . Devaki . Eichenlaub . Teresa . Herranz . Hector . Sridhar . Ts . Cohen . Stephen M . Shashidhara . Ls . Genome-Wide Screen for Context-Dependent Tumor Suppressors Identified Using in Vivo Models for Neoplasia in Drosophila . G3: Genes, Genomes, Genetics . September 2020 . 10 . 9 . 2999–3008 . 10.1534/g3.120.401545 . 32737065 . 7467006 . 220909235 .
- Kulkarni . Apurv . Kelkar . Devaki A. . Parikh . Nidhi . Shashidhara . Lingadahalli S. . Koppiker . Chaitanyanand B. . Kulkarni . Madhura . Meta-Analysis of Prevalence of Triple-Negative Breast Cancer and Its Clinical Features at Incidence in Indian Patients With Breast Cancer . JCO Global Oncology . November 2020 . 6 . 6 . 1052–1062 . 10.1200/go.20.00054 . 32639876 . 7392736 .
- De las Heras . José M. . García-Cortés . Celia . Foronda . David . Pastor-Pareja . José Carlos . Shashidhara . L. S. . Sánchez-Herrero . Ernesto . The Drosophila Hox gene Ultrabithorax controls appendage shape by regulating extracellular matrix dynamics . Development . 2018 . 145 . 13 . 10.1242/dev.161844 . 29853618 . 46923499 . free .
- Shukla . Jay Prakash . Deshpande . Girish . Shashidhara . L. S. . Ataxin-2 binding protein 1 is a context-specific positive regulator of Notch signaling during neurogenesis in Drosophila melanogaster . Development . 2017 . 144 . 5 . 905–915 . 10.1242/dev.140657 . 28174239 . 5374347 .
- Singh . Savita . Sánchez-Herrero . Ernesto . Shashidhara . L.S. . Critical role for Fat/Hippo and IIS/Akt pathways downstream of Ultrabithorax during haltere specification in Drosophila . Mechanisms of Development . November 2015 . 138 . 198–209 . 10.1016/j.mod.2015.07.017 . 26299254 . 5013529 . free . 10261/133365 . free .
- A comparative genomic analysis of targets of Hox protein Ultrabithorax amongst distant insect species . Naveen Prasad, Shreeharsha Tarikere, Dhanashree Khanale, Farhat Habib, Lingadahalli S Shashidhara . Scientific Reports . June 2016 . 6 . 27885 . 10.1038/srep27885 . 27296678 . 4906271. 2016NatSR...627885P .
- Book: ChIP for Hox Proteins from Drosophila Imaginal Discs . Pavan Agrawal, Lingadahalli S Shashidhara . Hox Genes . Methods in Molecular Biology . August 2013 . 1196 . 241–253 . 10.1007/978-1-4939-1242-1_15. 25151168 . 978-1-4939-1241-4 .
- Distinct Transcriptional Networks in Quiescent Myoblasts: A Role for Wnt Signaling in Reversible vs. Irreversible Arrest . Sindhu Subramaniam, Prethish Sreenivas, Sirisha Cheedipudi, Vatrapu Rami Reddy, Lingadahalli S Shashidhara, Ravi Kumar Chilukoti, Madhavi Mylavarapu, Jyotsna Dhawan . PLOS ONE . June 2013 . 8 . 6 . 10.1371/journal.pone.0065097 . 23755177 . 3670900 . e65097. 2013PLoSO...865097S . free .
- Drosophila apc regulates delamination of invasive epithelial clusters . F M De Graeve, Véronique Van De Bor, C Ghiglione, Stephane Noselli . Developmental Biology . May 2012 . 368 . 1 . 76–85 . 10.1016/j.ydbio.2012.05.017 . 22627290. free .
- Negative regulation ofUltrabithorax expression byengrailed is required for proper specification of wing development inDrosophila melanogaster . Bright Starling Emerald, Lingadahalli S Shashidhara . Journal of Genetics . April 2012 . 1 . 79 . 61–70 . 10.1007/BF02728947. 20816658 .
- Genome-level identification of targets of Hox protein Ultrabithorax in Drosophila: novel mechanisms for target selection . Pavan Agrawal, Farhat Habib, Ramesh Yelagandula, L. S. Shashidharaa . Scientific Reports . December 2011 . 1 . 205 . 205 . 10.1038/srep00205 . 22355720 . 3244697. 2011NatSR...1E.205A .
- The Drosophila Homologue of Ataxin-2 Binding Protein: Toward a Fruit Fly Model of Spinocerebellar Ataxia Type 2? . N Usha, LS Shashidhara . Alternatives to Laboratory Animals . March 2011 . 39 . 1 . 70.
- Human APC sequesters β-catenin even in the absence of GSK-3β in a Drosophila model . P R Rao, Kalpana Makhijani, Lingadahalli S Shashidhara . Oncogene . May 2008 . 27 . 17 . 2488–93 . 10.1038/sj.onc.1210890. 17968317 . free .
General Articles, Books and Policy Documents
Selected Videos and Podcasts
- "Science for Society: Science to Fight Covid-19 and Cancer: Perspectives from Pune", by Pune International Center (2021)
- "A journey in science...a journey in life", by BIIS (2021)
- "Science on the Pandemic and Science through the Pandemic", a webinar as a part of the Vigyan Setu Webinar Series by INSA-INYAS (2020)
- "Gender Equality in Science", a podcast by the International Science Council, as a part of the celebration of 'International Day of Women and Girls in Science', at UNESCO (2020)
- "COVID-19 and Animals: doubts clarified", by Talking It Up (2020)
- "Leadership and Mentoring", at the https://sites.google.com/view/felixbast/webinars/slw Science Leadership Workshop, (2020)
- "SDGs Learning, Training & Practice" as a part of the High-level Political Forum, by the United Nations (2019)
- "Why and how to integrate research and education?", uploaded by IndiaBioScience (2019)
- "QnA session with Professor L S Shashidhara, IISER Pune", uploaded by LivingScience (2016)
- "Eureka with Prof L S Shashidhara", uploaded by Rajya Sabha Television, an Indian public broadcast service (2016)
- "Impact of Science on Society", uploaded by LivingScience (2016)
- "NCBS Talk 1", uploaded by Bangalore Life Sciences Cluster (2010)
See also
External links
- Web site: Hox genes and evolution of body plan . Lecture – full text . Indian Institute of Science Education and Research . 2010 . 26 October 2016 . L. S. Shashidhara.
- Web site: NCBS talk 1 . Lecture – YouTube video . TheNCBSnewsteam's channel . 22 September 2010 . 26 October 2016 . L. S. Shashidhara.
Notes and References
- Web site: LSS Lab Home . LSS Lab – IISER . 2016 . 26 October 2016.
- Web site: L S Shashidhara – Biography . 2016 . IISER Thiruvananthapuram . 26 October 2016 .
- Web site: Indian fellow – Shashidhara . Indian National Science Academy . 2016 . 25 October 2016.
- Web site: Fellow Profile – Shashidhara . Indian Academy of Sciences . 2016 . 25 October 2016.
- Web site: NASI fellows . National Academy of Sciences, India . 2016 . 26 October 2016.
- Web site: View Bhatnagar Awardees . Shanti Swarup Bhatnagar Prize . 2016 . 5 October 2016.
- Web site: Brief Biodata . Centre for Cellular and Molecular Biology . 2016 . 26 October 2016.
- Web site: Drosophila Genetics & Developmental Biology . CCMB . 2016 . 26 October 2016.
- Web site: Prof. LS Shashidhara – LSS Lab . IISER, PUne . 2016 . 26 October 2016.
- Web site: Coordinator – Department of Biology . Open Access Biomedical Image Search Engine . 2016 . 26 October 2016.
- Web site: Handbook of Shanti Swarup Bhatnagar Prize Winners . Council of Scientific and Industrial Research . 1999 . 5 October 2016 . 34 . https://web.archive.org/web/20160304043957/http://www.csirhrdg.res.in/ssb.pdf . 4 March 2016 . dead .
- Web site: Publication by Fellows . Article listing . Indian Academy of Sciences . 2016 . 26 October 2016.
- Web site: Lingadahalli Subrahmanya Shashidhara on Metascience . Metascience . 2016 . 26 October 2016.
- Web site: Lingadahalli S Shashidhara on ResearchGate . 2016 . 26 October 2016.
- Web site: Behavioural Adaptations and Evolution . Featured talk . Centre for the Study of Culture and Society . 11 March 2010 . 26 October 2016 . L. S. Shashidhara.
- Web site: Cell Biology of Organ Development in Drosophila . IISER . 7 December 2015 . 26 October 2016 . https://web.archive.org/web/20161104071245/http://www.sandhyasekar.com/conf/session/l-s-shashidhara/ . 4 November 2016 . dead .
- Web site: IUBS Officers and Executive Committee Members . International Union of Biological Sciences . 2016 . 26 October 2016.
- Web site: 13 January 2016 . Prof. LS Shashidhara elected Vice President of the Indian National Science Academy . 26 October 2016 . IISER Pune News.