L-saccharopine oxidase explained

L-saccharopine oxidase
Ec Number:	1.5.3.18

L-saccharopine oxidase (FAP2) is an enzyme with systematic name L-saccharopine:oxygen oxidoreductase (L-glutamate forming).^{[1] [2]} This enzyme catalyses the following chemical reaction

N⁶-(L-1,3-dicarboxypropyl)-L-lysine + H₂O + O₂

\rightleftharpoons (S)-2-amino-6-oxohexanoate + L-glutamate + H₂O₂

The enzyme is involved in pipecolic acid biosynthesis.

Notes and References

1. Yoshida N, Akazawa S, Katsuragi T, Tani Y . Characterization of two fructosyl-amino acid oxidase homologs of Schizosaccharomyces pombe . Journal of Bioscience and Bioengineering . 97 . 4 . 278–80 . 2004 . 16233628 . 10.1016/S1389-1723(04)70204-2 .
2. Wickwire BM, Wagner C, Broquist HP . Pipecolic acid biosynthesis in Rhizoctonia leguminicola. II. Saccharopine oxidase: a unique flavin enzyme involved in pipecolic acid biosynthesis . The Journal of Biological Chemistry . 265 . 25 . 14748–53 . September 1990 . 2394693 .