L-peptidase explained

L-peptidase
Ec Number:	3.4.22.46

L-peptidase is an enzyme.^{[1] [2]} This enzyme catalyses the following chemical reaction

Autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-Gly bond. Subsequently, it cleaves host cell initiation factor eIF-4G at bonds -Gly-Arg- and -Lys-Arg-

This enzyme is coded bz foot-and-mouth disease virus.

Notes and References

1. Piccone ME, Zellner M, Kumosinski TF, Mason PW, Grubman MJ . Identification of the active-site residues of the L proteinase of foot-and-mouth disease virus . Journal of Virology . 69 . 8 . 4950–6 . August 1995 . 7609064 . 189310 .
2. Guarné A, Hampoelz B, Glaser W, Carpena X, Tormo J, Fita I, Skern T . Structural and biochemical features distinguish the foot-and-mouth disease virus leader proteinase from other papain-like enzymes . Journal of Molecular Biology . 302 . 5 . 1227–40 . October 2000 . 11183785 . 10.1006/jmbi.2000.4115 . 10261/111148 . free .