L-olivosyl-oleandolide 3-O-methyltransferase explained

L-olivosyl-oleandolide 3-O-methyltransferase
Ec Number:	2.1.1.239

L-olivosyl-oleandolide 3-O-methyltransferase (OleY) is an enzyme with systematic name S-adenosyl-L-methionine:L-olivosyl-oleandolide B 3-O-methyltransferase.^[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + L-olivosyl-oleandolide

\rightleftharpoons S-adenosyl-L-homocysteine + L-oleandrosyl-oleandolide

The enzyme is involved in the biosynthesis of the macrolide antibiotic oleandomycin in Streptomyces antibioticus.

Notes and References

1. Rodríguez L, Rodríguez D, Olano C, Braña AF, Méndez C, Salas JA . Functional analysis of OleY L-oleandrosyl 3-O-methyltransferase of the oleandomycin biosynthetic pathway in Streptomyces antibioticus . Journal of Bacteriology . 183 . 18 . 5358–63 . September 2001 . 11514520 . 95419 . 10.1128/jb.183.18.5358-5363.2001 .