L-methionine (S)-S-oxide reductase explained

L-methionine (S)-S-oxide reductase
Ec Number:	1.8.4.13

In enzymology, a L-methionine (S)-S-oxide reductase is an enzyme that catalyzes the chemical reaction

L-methionine + thioredoxin disulfide + H₂O

\rightleftharpoons L-methionine (S)-S-oxide + thioredoxin

The 3 substrates of this enzyme are L-methionine, thioredoxin disulfide, and H₂O, whereas its two products are L-methionine (S)-S-oxide and thioredoxin.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with a disulfide as acceptor. The systematic name of this enzyme class is L-methionine:thioredoxin-disulfide S-oxidoreductase. Other names in common use include fSMsr, methyl sulfoxide reductase I and II, acetylmethionine sulfoxide reductase, methionine sulfoxide reductase, L-methionine:oxidized-thioredoxin S-oxidoreductase, methionine-S-oxide reductase, and free-methionine (S)-S-oxide reductase. This enzyme participates in methionine metabolism.

References

• Black S, Harte EM, Hudson B, Wartofsky L . 1960 . A specific enzymatic reduction of L-(-)methionine sulfoxide and a related nonspecific reduction of diulfides . J. Biol. Chem. . 235 . 2910 - 2916 .
• Ejiri SI, Weissbach H, Brot N . 1979 . Reduction of methionine sulfoxide to methionine by Escherichia coli . J. Bacteriol. . 139 . 161 - 4 . 37234 . 1 . 216841 .
• Ejiri SI, Weissbach H, Brot N . 1980 . The purification of methionine sulfoxide reductase from Escherichia coli . Anal. Biochem. . 102 . 393 - 8 . 6999943 . 10.1016/0003-2697(80)90173-6 . 2 .
• Weissbach H, Resnick L, Brot N . 2005 . Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage . Biochim. Biophys. Acta . 1703 . 203 - 12 . 15680228 . 2 . 10.1016/j.bbapap.2004.10.004 .