L-iditol 2-dehydrogenase explained

L-iditol 2-dehydrogenase
Ec Number:1.1.1.14
Cas Number:9028-21-1
Go Code:0003939
Width:270

In enzymology, a L-iditol 2-dehydrogenase is an enzyme that catalyzes the chemical reaction

L-iditol + NAD+ L-sorbose + NADH + H+

Thus, the two substrates of this enzyme are L-iditol and NAD+, whereas its 3 products are L-sorbose, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-iditol:NAD+ 2-oxidoreductase. Other names in common use include polyol dehydrogenase, sorbitol dehydrogenase, L-iditol:NAD+ 5-oxidoreductase, L-iditol (sorbitol) dehydrogenase, glucitol dehydrogenase, L-iditol:NAD+ oxidoreductase, NAD+-dependent sorbitol dehydrogenase, NAD+-dependent sorbitol dehydrogenase, and NAD+-sorbitol dehydrogenase. This enzyme participates in fructose and mannose metabolism.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes,,, and .

References

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "L-iditol 2-dehydrogenase".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.