L-galactose 1-dehydrogenase explained

L-galactose 1-dehydrogenase
Ec Number:	1.1.1.316

L-galactose 1-dehydrogenase (L-GalDH, L-galactose dehydrogenase) is an enzyme with the systematic name L-galactose:NAD⁺ 1-oxidoreductase.^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction:

L-galactose + NAD⁺

\rightleftharpoons L-galactono-1,4-lactone + NADH + H⁺

The enzyme catalyses a step in the ascorbate biosynthesis in higher plants.

Notes and References

1. Mieda T, Yabuta Y, Rapolu M, Motoki T, Takeda T, Yoshimura K, Ishikawa T, Shigeoka S . Feedback inhibition of spinach L-galactose dehydrogenase by L-ascorbate . Plant & Cell Physiology . 45 . 9 . 1271–9 . September 2004 . 15509850 . 10.1093/pcp/pch152 . free .
2. Gatzek S, Wheeler GL, Smirnoff N . Antisense suppression of l-galactose dehydrogenase in Arabidopsis thaliana provides evidence for its role in ascorbate synthesis and reveals light modulated l-galactose synthesis . The Plant Journal . 30 . 5 . 541–53 . June 2002 . 12047629 . 10.1046/j.1365-313x.2002.01315.x . free .
3. Wheeler GL, Jones MA, Smirnoff N . The biosynthetic pathway of vitamin C in higher plants . Nature . 393 . 6683 . 365–9 . May 1998 . 9620799 . 10.1038/30728 .
4. Oh MM, Carey EE, Rajashekar CB . Environmental stresses induce health-promoting phytochemicals in lettuce . Plant Physiology and Biochemistry . 47 . 7 . 578–83 . July 2009 . 19297184 . 10.1016/j.plaphy.2009.02.008 .