L-fuculose-phosphate aldolase explained

L-fuculose-phosphate aldolase
Ec Number:	4.1.2.17
Cas Number:	9024-54-8
Go Code:	0008738

The enzyme L-fuculose-phosphate aldolase catalyzes the chemical reaction

L-fuculose-1-phosphate

\rightleftharpoons glycerone phosphate^[1] + (S)-lactaldehyde

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is L-fuculose-1-phosphate (S)-lactaldehyde-lyase (glycerone-phosphate-forming). Other names in common use include L-fuculose 1-phosphate aldolase, fuculose aldolase, and L-fuculose-1-phosphate lactaldehyde-lyase. This enzyme participates in fructose and mannose metabolism.

Structural studies

As of late 2007, 20 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,,,,,,,,,,,,, and .

See also

• Fuculose
• L-Fuculose kinase

References

• Ghalambor MA, Heath EC . 1966 . The biosynthesis of cell wall lipopolysaccharide in Escherichia coli. IV. Purification and properties of cytidine monophosphate 3-deoxy-d-manno-octulosonate synthetase . J. Biol. Chem. . 241 . 3216 - 21 . 5330266 . 13 .
• Dreyer MK, Schulz GE . 1993 . The spatial structure of the class II L-fuculose-1-phosphate aldolase from Escherichia coli . J. Mol. Biol. . 231 . 549 - 53 . 8515438 . 10.1006/jmbi.1993.1307 . 3 .
• Dreyer MK, Schulz GE . 1996 . Catalytic mechanism of the metal-dependent fuculose aldolase from Escherichia coli as derived from the structure . J. Mol. Biol. . 259 . 458 - 66 . 8676381 . 10.1006/jmbi.1996.0332 . 3 .

Notes and References

1. Glycerone phosphate is often known as dihydroxyacetone phosphate.