L-amino-acid dehydrogenase explained

L-amino-acid dehydrogenase
Ec Number:	1.4.1.5
Cas Number:	9029-13-4
Go Code:	0050018

In enzymology, a L-amino-acid dehydrogenase is an enzyme that catalyzes the chemical reaction

an L-amino acid + H₂O + NAD⁺

\rightleftharpoons a 2-oxo acid + NH₃ + NADH + H⁺

The 3 substrates of this enzyme are L-amino acid, H₂O, and NAD⁺, whereas its 4 products are 2-oxo acid, NH₃, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-amino-acid:NAD+ oxidoreductase (deaminating).

References

• Nisman B, Mager J . Diphosphopyridine nucleotide and phosphate requirement for oxidation of amino-acids by cell-free extracts of obligate anaerobes . Nature . 169 . 4293 . 243–4 . February 1952 . 14910739 . 10.1038/169243a0 .