L-759,633 Explained

L-759,633 is an analgesic drug that is a cannabinoid agonist. It is a fairly selective agonist for the CB₂ receptor, with selectivity of 163x for CB₂ over CB₁.^[1]

It produces some similar effects to other cannabinoid agonists such as analgesia, but with little or no sedative or psychoactive effects due to its weak CB₁ activity, and a relatively strong antiinflammatory effect due to its strong activity at CB₂.^{[2] [3]}

See also

• L-759,656
• L-768,242

Notes and References

1. Ross RA, Brockie HC, Stevenson LA, Murphy VL, Templeton F, Makriyannis A, Pertwee RG . Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630 . British Journal of Pharmacology . 126 . 3 . 665–72 . February 1999 . 10188977 . 1565857 . 10.1038/sj.bjp.0702351 . Alexandros Makriyannis .
2. Huffman JW . The search for selective ligands for the CB2 receptor . Current Pharmaceutical Design . 6 . 13 . 1323–37 . September 2000 . 10903395 . 10.2174/1381612003399347 .
3. Huffman JW . CB2 receptor ligands . Mini Reviews in Medicinal Chemistry . 5 . 7 . 641–9 . July 2005 . 16026310 . 10.2174/1389557054368844 .