L-745,870 Explained

L-745,870 is a drug which acts as a dopamine receptor antagonist selective for the D4 subtype, and has antipsychotic effects in animal models, though it was not effective in human trials.[1] [2] [3]

Notes and References

  1. Bristow LJ, Kramer MS, Kulagowski J, Patel S, Ragan CI, Seabrook GR . Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist . Trends in Pharmacological Sciences . 18 . 6 . 186–8 . June 1997 . 9226994 . 10.1016/s0165-6147(97)01066-3.
  2. Zhang K, Grady CJ, Tsapakis EM, Andersen SL, Tarazi FI, Baldessarini RJ . Regulation of working memory by dopamine D4 receptor in rats . Neuropsychopharmacology . 29 . 9 . 1648–55 . September 2004 . 15138447 . 10.1038/sj.npp.1300491 . free .
  3. Moustgaard A, Hau J, Lind NM . Effects of dopamine D4 receptor antagonist on spontaneous alternation in rats . Behavioral and Brain Functions . 4 . 49 . 2008 . 18945334 . 2577092 . 10.1186/1744-9081-4-49 . free .

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