| L'Isle-d'Espagnac | |
| Commune Status: | Commune |
| Image Coat Of Arms: | Blason ville fr L'Isle-d'Espagnac (Charente).svg |
| Arrondissement: | Angoulême |
| Canton: | Angoulême-2 |
| Insee: | 16166 |
| Postal Code: | 16340 |
| Mayor: | Michel Issard[1] |
| Term: | 2020 - 2026 |
| Intercommunality: | Grand Angoulême |
| Coordinates: | 45.6622°N 0.2006°W |
| Elevation Min M: | 38 |
| Elevation Max M: | 120 |
| Area Km2: | 5.95 |
L'Isle-d'Espagnac (in French pronounced as /lil depaɲak/) is a commune in the Charente department in southwestern France.