| L'Épine | |
| Commune Status: | Commune |
| Image Coat Of Arms: | Blason ville fr L'Épine (Hautes-Alpes).svg |
| Arrondissement: | Gap |
| Canton: | Serres |
| Insee: | 05048 |
| Postal Code: | 05700 |
| Mayor: | Luc Delaup[1] |
| Term: | 2020 - 2026 |
| Coordinates: | 44.4181°N 5.6175°W |
| Elevation M: | 840 |
| Elevation Min M: | 785 |
| Elevation Max M: | 1760 |
| Area Km2: | 33.47 |
L'Épine (in French pronounced as /lepin/; Occitan (post 1500);: L'Espina) is a commune in the Hautes-Alpes department in southeastern France.