Kv channel interacting protein explained

Kv channel interacting proteins are members of a family of voltage-gated potassium (K_v) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily.^[1] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native K_v4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.^[2]

Members of this family include:

• KCNIP1, a protein that in humans is encoded by the KCNIP1 gene.^{[3] [2]}
• KCNIP2, a protein that in humans is encoded by the KCNIP2 gene.^{[3] [2]}
• KCNIP3, more commonly known as Calsenilin, a protein that in humans is encoded by the KCNIP3 gene.^{[4] [5] [2]}
• KCNIP4, a protein that in humans is encoded by the KCNIP4 gene.^{[6] [7] [2]}

Notes and References

1. Burgoyne RD. Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling. Nat. Rev. Neurosci. . 8 . 3 . 182–193 . 2007 . 17311005 . 1887812 . 10.1038/nrn2093 .
2. Web site: Entrez Gene: KCNIP1 Kv channel interacting protein 1.
3. An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ . Modulation of A-type potassium channels by a family of calcium sensors . Nature . 403 . 6769 . 553–556 . Feb 2000 . 10676964 . 10.1038/35000592 . 2000Natur.403..553A . 4419472 .
4. Buxbaum JD, Choi EK, Luo Y, Lilliehook C, Crowley AC, Merriam DE, Wasco W . Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment . Nat Med . 4 . 10 . 1177–81 . October 1998 . 9771752 . 10.1038/2673 . 10799492 .
5. Carrión AM, Link WA, Ledo F, Mellström B, Naranjo JR . DREAM is a Ca2+-regulated transcriptional repressor . Nature . 398 . 6722 . 80–4 . March 1999 . 10078534 . 10.1038/18044 . 1999Natur.398...80C . 204991618 .
6. Holmqvist MH, Cao J, Hernandez-Pineda R, Jacobson MD, Carroll KI, Sung MA, Betty M, Ge P, Gilbride KJ, Brown ME, Jurman ME, Lawson D, Silos-Santiago I, Xie Y, Covarrubias M, Rhodes KJ, Distefano PS, An WF . Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain . Proc Natl Acad Sci U S A . 99 . 2 . 1035–40 . Jan 2002 . 11805342 . 117799 . 10.1073/pnas.022509299 . 2002PNAS...99.1035H . free .
7. Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, Imaizumi Y, Tomita T, Iwatsubo T . Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4 . J Biol Chem . 277 . 17 . 14965–75 . Apr 2002 . 11847232 . 10.1074/jbc.M200897200 . free .