| Kumasi Girls Senior High School | |
| Streetaddress: | P. O. Box KS, Kumasi |
| Region: | Ashanti Region |
| Town: | Kumasi |
| Country: | Ghana |
| Religion: | Christianity - Methodist |
| Oversight: | Ministry of Education |
| Founder: | Caxton Williams |
| Head Label: | Headmistress |
| Head: | Cecilia Nana Yeboah |
| Chaplain: | Sophia Nyarko Manu |
| Ranking: | First Choice |
| Classes Offered: | General Arts, General Science, Business, Home Economics, Visual Arts |
| Gender: | Girls |
| Lower Age: | 14 |
| Upper Age: | 18 |
| Houses: | 7 |
| Schooltype: | All Girls School |
| Type: | Public High School |
| Language: | English |
| Motto: | SEMPER FIDELIS |
| Sports: | All sports |
| Nickname: | KUGISS |
| Founded: | 1953 |
| Status: | active |
| Alumni: | AHEMAA |
Kumasi Girls is located at Abrepo, a suburb of Kumasi in the Ashanti region of Ghana. The school is adjacent to the County hospital.
The school was started as a private secondary school for girls by Caxton Williams, a Sierra Leonean in 1953.Kumasi Girls' Senior High School (KUGISS) was first situated at Susanso, near Bomso Junction on the Kumasi-Accra road. In the early 1960s, the proprietor moved the school to Old Tafo where it remained in rented premises until 1992 when the school was moved to its present and permanent site at Abrepo. The government took over the administration of the school in the year 1963.
Kumasi Girls maintains an ongoing alliance with their boys' school, Kumasi High School called MMRAHEMMAA.