| Kukpuk River | |
| Map Size: | 300 |
| Pushpin Map: | USA Alaska |
| Pushpin Map Size: | 300 |
| Pushpin Map Caption: | Location of the mouth of the Kukpuk River in Alaska |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States |
| Subdivision Type2: | State |
| Subdivision Name2: | Alaska |
| Subdivision Type4: | Borough |
| Subdivision Name4: | North Slope |
| Length: | 125miles[1] |
| Source1: | De Long Mountains |
| Source1 Coordinates: | 68.3242°N -163.415°W |
| Source1 Elevation: | 2092feet[2] |
| Mouth: | East end of Marryat Inlet |
| Mouth Location: | 12miles northeast of Point Hope, Chukchi Sea, Arctic Ocean |
| Mouth Coordinates: | 68.4158°N -166.3769°W[3] |
| Mouth Elevation: | 0feet |
The Kukpuk River (Iñupiaq: Kuukpak) is a stream, about 125miles long, in the western North Slope Borough of the U.S. state of Alaska.[1] It flows generally west from the De Long Mountains across the Lisburne Peninsula to Marryat Inlet on the Chukchi Sea.[4] The river mouth is about 12miles northeast of Point Hope.[3]
The Inuit name "Kuukpak" means "big river". A late 19th-century variant was "Kookpuk".[3]