| Kukpowruk River | |
| Map Size: | 300 |
| Pushpin Map: | USA Alaska |
| Pushpin Map Size: | 300 |
| Pushpin Map Caption: | Location of the mouth of the Kukpowruk River in Alaska |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States |
| Subdivision Type2: | State |
| Subdivision Name2: | Alaska |
| Subdivision Type4: | Borough |
| Subdivision Name4: | North Slope |
| Length: | 160miles[1] |
| Source1: | De Long Mountains |
| Source1 Coordinates: | 68.4389°N -162.4969°W |
| Source1 Elevation: | 2872feet[2] |
| Mouth: | Kasegaluk Lagoon, Chukchi Sea, Arctic Ocean |
| Mouth Location: | 9miles south of Point Lay |
| Mouth Coordinates: | 69.6158°N -163.0183°W[3] |
| Mouth Elevation: | 0feet |
The Kukpowruk River is a stream, 160miles long, in the western North Slope Borough of the U.S. state of Alaska.[1] It arises in the De Long Mountains of the western Brooks Range and flows north into Kasegaluk Lagoon of the Chukchi Sea, Arctic Ocean.[3] The river mouth is about 9miles south of Point Lay.[3] Arctic Slope Regional Corporation is the major landowner along the river.
The Inuit name for the river probably means "fairly large stream" or "a stream."[3] A late 19th-century variant was "Kook Pow ruk."[3]