Kua-UEV explained

Ubiquitin-conjugating enzyme E2 variant 1, also known as Kua-UEV, is a human gene.^[1]

The Kua-UEV mRNA is an infrequent but naturally occurring co-transcribed product of the neighboring Kua and UBE2V1 genes.^[2] Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. Two alternative transcripts encoding different isoforms have been described. The proteins produced by these transcripts have UEV1 B domains but the proteins are localized to the cytoplasm rather than to the nucleus. The significance of these co-transcribed mRNAs and the function of their protein products have not yet been determined.

Further reading

• Long M . A new function evolved from gene fusion . Genome Research . 10 . 11 . 1655–7 . November 2000 . 11076848 . 10.1101/gr.165700 . free .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . September 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Rothofsky ML, Lin SL . CROC-1 encodes a protein which mediates transcriptional activation of the human FOS promoter . Gene . 195 . 2 . 141–9 . August 1997 . 9305758 . 10.1016/S0378-1119(97)00097-8 .
• Sancho E, Vilá MR, Sánchez-Pulido L, Lozano JJ, Paciucci R, Nadal M, Fox M, Harvey C, Bercovich B, Loukili N, Ciechanover A, Lin SL, Sanz F, Estivill X, Valencia A, Thomson TM . 6 . Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells . Molecular and Cellular Biology . 18 . 1 . 576–89 . January 1998 . 9418904 . 121525 . 10.1128/mcb.18.1.576 .
• Xiao W, Lin SL, Broomfield S, Chow BL, Wei YF . The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family . Nucleic Acids Research . 26 . 17 . 3908–14 . September 1998 . 9705497 . 147796 . 10.1093/nar/26.17.3908 .
• Ma L, Broomfield S, Lavery C, Lin SL, Xiao W, Bacchetti S . Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines . Oncogene . 17 . 10 . 1321–6 . September 1998 . 9771976 . 10.1038/sj.onc.1202058 . 9281963 .
• Hofmann RM, Pickart CM . Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair . Cell . 96 . 5 . 645–53 . March 1999 . 10089880 . 10.1016/S0092-8674(00)80575-9 . 17117789 . free .
• Deng L, Wang C, Spencer E, Yang L, Braun A, You J, Slaughter C, Pickart C, Chen ZJ . 6 . Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain . Cell . 103 . 2 . 351–61 . October 2000 . 11057907 . 10.1016/S0092-8674(00)00126-4 . 18154645 . free .
• Thomson TM, Lozano JJ, Loukili N, Carrió R, Serras F, Cormand B, Valeri M, Díaz VM, Abril J, Burset M, Merino J, Macaya A, Corominas M, Guigó R . 6 . Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene . Genome Research . 10 . 11 . 1743–56 . November 2000 . 11076860 . 310942 . 10.1101/gr.GR-1405R .
• Dias DC, Dolios G, Wang R, Pan ZQ . CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex . Proceedings of the National Academy of Sciences of the United States of America . 99 . 26 . 16601–6 . December 2002 . 12481031 . 139190 . 10.1073/pnas.252646399 . free .
• Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY . 6 . Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress . Biochemical and Biophysical Research Communications . 337 . 4 . 1308–18 . December 2005 . 16236267 . 10.1016/j.bbrc.2005.09.191 .

Notes and References

1. Web site: Entrez Gene: Kua-UEV ubiquitin-conjugating enzyme E2 variant 1.
2. Thomson TM, Lozano JJ, Loukili N, Carrió R, Serras F, Cormand B, Valeri M, Díaz VM, Abril J, Burset M, Merino J, Macaya A, Corominas M, Guigó R . 6 . Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene . Genome Research . 10 . 11 . 1743–56 . November 2000 . 11076860 . 310942 . 10.1101/gr.gr-1405r .