Koningic acid explained

Koningic acid (KA, also known as heptelidic acid) is a potent, selective, irreversible GAPDH inhibitor.[1] [2] It is also a DNA polymerase inhibitor. The koningic acid molecule, produced by fungi that consume sweet potatoes, has been shown to curb the excessive glucose consumption in tumors exhibiting the Warburg effect and leaving healthy cells alone.[3]

Notes and References

  1. Web site: Heptelidic acid (Koningic acid) - Abcam. www.abcam.com.
  2. 10.7164/antibiotics.38.920 . 4030504 . Specific inhibition of glyceraldehyde-3-phosphate dehydrogenase by koningic acid (Heptelidic acid) . The Journal of Antibiotics . 38 . 7 . 920–5 . 1985 . Endo . Akira . Hasum . Kenji . Hasumi . Kenji . Sakai . Kaoru . Kanbe . Tomomi . free .
  3. Web site: Natural molecule appears to shut off cancer cells' energy source.

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