| Koko River | |
| Mouth Coordinates: | -2.61°N 29.1866°W |
| Subdivision Type1: | Country |
| Tributaries Left: | Shyara River |
The Koko River is a river in the Rusizi District of southwestern Rwanda that is a right-hand tributary of the Ruhwa River, which forms the boundary between the western regions of Rwanda and Burundi. For most of its length it runs through the Nyungwe National Park.