Kobophenol A Explained

Kobophenol A is a stilbenoid. It is a tetramer of resveratrol. It can be isolated from Caragana chamlagu,^[1] from Caragana sinica^[2] and from Carex folliculata seeds.^[3]

The molecule shows a 2,3,4,5-tetraaryltetrahydrofuran skeleton.^[3]

It has been shown to inhibit acetylcholinesterase.^[1]

Acid-catalyzed epimerization of kobophenol A to carasinol B can be performed in vitro.^[4]

Notes and References

1. http://www.jstage.jst.go.jp/article/bpb/25/1/25_125/_article/-char/en (+)-α-Viniferin, a Stilbene Trimer from Caragana chamlague, Inhibits Acetylcholinesterase. Sang Hyun Sung, So Young Kang, Ki Yong Lee, Mi Jung Park, Jeong Hun Kim, Jong Hee Park, Young Chul Kim, Jinwoong Kim and Young Choong Kim, Biological & Pharmaceutical Bulletin, Vol. 25, 2002
2. http://cat.inist.fr/?aModele=afficheN&cpsidt=17780314 Simultaneous determination of the contents of three stilbene oligomers in Caragana sinica collected in different seasons using an improved HPLC method. Shu Na; Zhou Hong; Hu Changqi, Biological & pharmaceutical bulletin, 2006, vol. 29, no4, pp. 608-612
3. Identification and bioactivities of resveratrol oligomers and flavonoids from Carex folliculata seeds. Li L, Henry GE and Seeram NP, J Agric Food Chem., 26 August 2009, volume 57, issue 16, pages 7282-7287,
4. http://www.mdpi.com/1420-3049/13/4/938 Acid-catalyzed Epimerization of Kobophenol A to Carasinol B. Kejun Cheng, Gaolin Liang and Changqi Hu, Molecules 2008, 13(4), 938-942