| Knox County Courthouse | |
| Location: | High St., Mount Vernon, Ohio |
| Coordinates: | 40.3936°N -82.4825°W |
| Built: | 1855 |
| Architect: | Daniel Clark; John Jennings |
| Architecture: | Greek Revival |
| Added: | June 4, 1973 |
| Refnum: | 73001484 |
The Knox County Courthouse is a historic building located on High Street in Mount Vernon, Ohio, United States. It was built in 1855 in the Greek Revival style of architecture. It was listed on the National Register of Historic Places in 1973.