| Knob Noster High School | |
| Grades: | 912 |
| Enrollment: | 426 (2021–2022)[1] |
| Faculty: | 35.91 (FTE) |
| Ratio: | 11.86 |
| Mascot: | Panther |
| Address: | 504 S Washington |
| Location: | Knob Noster, Missouri 65336 |
| Country: | USA |
| Coordinates: | 38.7609°N -93.561°W |
Knob Noster High School is an American public high school located in Knob Noster, Missouri. It is part of the Knob Noster R-VIII School District.