| Official Name: | Knob Lick, Missouri |
| Settlement Type: | Census-Designated Place |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | Missouri |
| Subdivision Type2: | County |
| Subdivision Name2: | Saint Francois |
| Unit Pref: | Imperial |
| Area Footnotes: | [1] |
| Area Total Km2: | 2.57 |
| Area Land Km2: | 2.57 |
| Area Water Km2: | 0.00 |
| Area Total Sq Mi: | 0.99 |
| Area Land Sq Mi: | 0.99 |
| Area Water Sq Mi: | 0.00 |
| Population As Of: | 2020 |
| Population Total: | 147 |
| Population Density Km2: | 57.10 |
| Population Density Sq Mi: | 147.89 |
| Elevation Ft: | 948 |
| Postal Code: | 63651 |
| Blank Name: | FIPS code |
| Blank Info: | 29-39170 |
| Blank1 Name: | GNIS feature ID |
| Blank1 Info: | 2806425 |
Knob Lick is an unincorporated community in southern Saint Francois County, Missouri, United States. It is located on Missouri Route DD, just east of U.S. Route 67, approximately eight miles south of Farmington.
Knob Lick has a post office with zip code 63651,[2] which has been in operation since 1870.[3] The community takes its name from nearby Knob Lick Mountain. In the Ozarks, knob typically refers to an isolated summit, and lick is a natural "salt lick" or salt spring.[4] [5] The mountain is across U.S. Route 67 from the town at 37.6645°N -90.3859°W. Eighty (80acres) of the summit are protected by the Missouri Department of Conservation. A gravel road leads to the conservation area which includes a granite glade, picnic facilities, and a closed fire lookout tower.[6]