KLF5 explained

Krueppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene.^{[1] [2]}

Function

This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor.

Interactions

KLF5 has been shown to interact with Protein SET.^[3]

Clinical significance

KLF5 expression has been linked to higher survival rates for lung cancer patients.^[4]

See also

• Kruppel-like factors

Further reading

• Ghaleb AM, Nandan MO, Chanchevalap S, Dalton WB, Hisamuddin IM, Yang VW . Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation . Cell Research . 15 . 2 . 92–6 . Feb 2005 . 15740636 . 1317089 . 10.1038/sj.cr.7290271 .
• Nagai R, Suzuki T, Aizawa K, Shindo T, Manabe I . Significance of the transcription factor KLF5 in cardiovascular remodeling . Journal of Thrombosis and Haemostasis . 3 . 8 . 1569–76 . Aug 2005 . 16102021 . 10.1111/j.1538-7836.2005.01366.x . free .
• McConnell BB, Ghaleb AM, Nandan MO, Yang VW . The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology . BioEssays . 29 . 6 . 549–57 . Jun 2007 . 17508399 . 2211634 . 10.1002/bies.20581 .
• Kojima S, Kobayashi A, Gotoh O, Ohkuma Y, Fujii-Kuriyama Y, Sogawa K . Transcriptional activation domain of human BTEB2, a GC box-binding factor . Journal of Biochemistry . 121 . 2 . 389–96 . Feb 1997 . 9089417 . 10.1093/oxfordjournals.jbchem.a021600 .
• Conkright MD, Wani MA, Anderson KP, Lingrel JB . A gene encoding an intestinal-enriched member of the Krüppel-like factor family expressed in intestinal epithelial cells . Nucleic Acids Research . 27 . 5 . 1263–70 . Mar 1999 . 9973612 . 148310 . 10.1093/nar/27.5.1263 .
• Shi H, Zhang Z, Wang X, Liu S, Teng CT . Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter . Nucleic Acids Research . 27 . 24 . 4807–15 . Dec 1999 . 10572182 . 148782 . 10.1093/nar/27.24.4807 .
• Hoshino Y, Kurabayashi M, Kanda T, Hasegawa A, Sakamoto H, Okamoto E, Kowase K, Watanabe N, Manabe I, Suzuki T, Nakano A, Takase S, Wilcox JN, Nagai R . Regulated expression of the BTEB2 transcription factor in vascular smooth muscle cells: analysis of developmental and pathological expression profiles shows implications as a predictive factor for restenosis . Circulation . 102 . 20 . 2528–34 . Nov 2000 . 11076828 . 10.1161/01.cir.102.20.2528 . free .
• Sun R, Chen X, Yang VW . Intestinal-enriched Krüppel-like factor (Krüppel-like factor 5) is a positive regulator of cellular proliferation . The Journal of Biological Chemistry . 276 . 10 . 6897–900 . Mar 2001 . 11152667 . 2268089 . 10.1074/jbc.C000870200 . free .
• Dang DT, Zhao W, Mahatan CS, Geiman DE, Yang VW . Opposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene . Nucleic Acids Research . 30 . 13 . 2736–41 . Jul 2002 . 12087155 . 117055 . 10.1093/nar/gkf400 .
• Shindo T, Manabe I, Fukushima Y, Tobe K, Aizawa K, Miyamoto S, Kawai-Kowase K, Moriyama N, Imai Y, Kawakami H, Nishimatsu H, Ishikawa T, Suzuki T, Morita H, Maemura K, Sata M, Hirata Y, Komukai M, Kagechika H, Kadowaki T, Kurabayashi M, Nagai R . Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling . Nature Medicine . 8 . 8 . 856–63 . Aug 2002 . 12101409 . 10.1038/nm738 . 34181151 .
• Sur I, Undén AB, Toftgård R . Human Krüppel-like factor5/KLF5: synergy with NF-kappaB/Rel factors and expression in human skin and hair follicles . European Journal of Cell Biology . 81 . 6 . 323–34 . Jun 2002 . 12113473 . 10.1078/0171-9335-00257 .
• Chen C, Bhalala HV, Qiao H, Dong JT . A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer . Oncogene . 21 . 43 . 6567–72 . Sep 2002 . 12242654 . 10.1038/sj.onc.1205817 . free .
• Yang XO, Doty RT, Hicks JS, Willerford DM . Regulation of T-cell receptor D beta 1 promoter by KLF5 through reiterated GC-rich motifs . Blood . 101 . 11 . 4492–9 . Jun 2003 . 12576331 . 10.1182/blood-2002-08-2579 . free .
• Chen C, Bhalala HV, Vessella RL, Dong JT . KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer . The Prostate . 55 . 2 . 81–8 . May 2003 . 12661032 . 10.1002/pros.10205 . 21150851 .
• Zhang Z, Teng CT . Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function . Nucleic Acids Research . 31 . 8 . 2196–208 . Apr 2003 . 12682370 . 153738 . 10.1093/nar/gkg310 .
• Ohnishi S, Ohnami S, Laub F, Aoki K, Suzuki K, Kanai Y, Haga K, Asaka M, Ramirez F, Yoshida T . Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer . Biochemical and Biophysical Research Communications . 308 . 2 . 251–6 . Aug 2003 . 12901861 . 10.1016/S0006-291X(03)01356-1 .
• Aizawa K, Suzuki T, Kada N, Ishihara A, Kawai-Kowase K, Matsumura T, Sasaki K, Munemasa Y, Manabe I, Kurabayashi M, Collins T, Nagai R . Regulation of platelet-derived growth factor-A chain by Krüppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaB . The Journal of Biological Chemistry . 279 . 1 . 70–6 . Jan 2004 . 14573617 . 10.1074/jbc.M306621200 . free .
• Sato T, Kanda T, Iida T, Takahashi T, Kishi S, Hoshino Y . Immunohistochemical study of surgically excised choroidal neovascular membranes . The Journal of International Medical Research . 31 . 5 . 402–6 . 2004 . 14587307 . 10.1177/147323000303100507 . 33670045 . free .

Notes and References

1. Sogawa K, Imataka H, Yamasaki Y, Kusume H, Abe H, Fujii-Kuriyama Y . cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2 . Nucleic Acids Research . 21 . 7 . 1527–32 . Apr 1993 . 8479902 . 309358 . 10.1093/nar/21.7.1527 .
2. Web site: Entrez Gene: KLF5 Kruppel-like factor 5 (intestinal).
3. Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, Nagino T, Imai Y, Adachi N, Horikoshi M, Nagai R . Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain . Molecular and Cellular Biology . 23 . 23 . 8528–41 . Dec 2003 . 14612398 . 262669 . 10.1128/MCB.23.23.8528-8541.2003 .
4. Web site: Research update from the MCM team (May 2024). World Community Grid. 13 May 2024. 21 May 2024.