| Klaus Aeffke | |
| Nocat Wdimage: | yes |
| Birth Place: | Neustrelitz, Mecklenburg, Germany |
| Height: | 1.89 m |
| Weight: | 82 kg |
| Sport: | Rowing |
| Club: | Ratzeburger RC |
| Show-Medals: | yes |
Klaus Aeffke (born 9 May 1940) is a retired German rower who was most successful in the eights. In this event he won a silver medal at the 1964 Summer Olympics, a world title in 1962, and three European titles in 1963–1965.