Klaus-Peter Lesch Explained

Klaus-Peter Lesch is a German clinical psychiatrist who has been investigating the neurobiological foundation of personality traits.^[1] His 1996 paper^[2] on the association between the 5-HTTLPR polymorphism in the serotonin transporter gene and the personality trait neuroticism has been highly cited and was one of the first papers in personality genetics.

He is professor at the University of Würzburg.Among his coauthors has been Peter Riederer. In 2008, he received the ECNP Neuropsychopharmacology Award.^[3]

Important Publications

• Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Müller CR, Hamer DH, Murphy DL . 1996 . Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region . Science . 274 . 5292. 1527–1532 . 10.1126/science.274.5292.1527 . 8929413. 1996Sci...274.1527L . 35503987 .
• Canli T, Lesch KP . 2007 . Long story short: the serotonin transporter in emotion regulation and social cognition . Nature Neuroscience . 10 . 9. 1103–1109 . 10.1038/nn1964 . 17726476. 7624807 .
• Murphy DL, Lesch KP . 2008 . Targeting the murine serotonin transporter: insights into human neurobiology . Nat Rev Neurosci . 9 . 2. 85–96 . 10.1038/nrn2284 . 18209729. 7563088 .
• Lesch KP, Selch S, Renner TJ, Jacob C, Nguyen TT, Hahn T, Romanos M, Shoichet S, Dempfle A, Heine M, Boreatti-Hümmer A, Walitza S, Romanos J, Gross-Lesch S, Zerlaut H, Allolio B, Heinzel S, Fassnacht M, Fallgatter A, Wultsch T, Schäfer H, Warnke A, Reif A, Ropers HH, Ullmann R . 2011 . Genome-wide copy number variation analysis in ADHD: association with neuropeptide Y gene dosage in an extended pedigree . Mol Psychiatry . 16 . 5 . 491–503 . 10.1038/mp.2010.29. 20308990 . 14391076 . free .
• Lesch KP, Waider J . 2012 . Serotonin in the modulation of neural plasticity and networks: implications for neurodevelopmental disorders . Neuron . 76 . 1 . 175–191 . 10.1016/j.neuron.2012.09.013. 23040814 . free .

External links

• Klaus-Peter Lesch at Würzburg University

Notes and References

1. Web site: Interview with Prof. Dr. K.P. Lesch . in-cites.
2. 10.1126/science.274.5292.1527. Klaus-Peter . Lesch. D. . Bengel. A. . Heils. S. Z. . Sabol. B. D. . Greenberg. S. . Petri. J. . Benjamin. C. R. . Muller. D. H. . Hamer. D. L. . Murphy . Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region . . 274 . 5292 . 1527–31 . November 1996 . 8929413. 1996Sci...274.1527L . 35503987 .
3. Web site: ECNP Neuropsychopharmacology Award winners . 2024-08-01 . www.ecnp.eu.