Kim Jae Kyoung Explained

Kim Jae Kyoung should not be confused with Kim Jae-kyung.

Birth Date:14 December 1982
Birth Place:Daegu, South Korea
Fields:Mathematical biology, circadian rhythms, sleep, single-cell sequencing, cancer, multi-scale stochastic systems, machine learning, pharmacosytems model
Workplaces:Institute for Basic Science, KAIST, Korea Institute for Advanced Study, University of Michigan, Mathematical Biosciences Institute
Education:PhD
Alma Mater:University of Michigan, Seoul National University
Thesis Title:Mathematical Modeling and Analysis of Cellular Clocks
Thesis Url:https://deepblue.lib.umich.edu/handle/2027.42/99957
Thesis Year:2012
Doctoral Advisor:Daniel Forger, Victoria Booth
Academic Advisors:Trachette Jackson
Spouses:)-->
Partners:)-->
Website:IBS Biomedical Mathematics Group
Lab at KAIST
Module:
Hangul:김재경
Rr:Gim Jaegyeong
Mr:Kim Chaegyŏng
Child:yes

Kim Jae Kyoung (; born December 14, 1982) is a biomedical mathematician and associate professor at KAIST in the Department of Mathematical Sciences[1] [2] and a chief investigator in the Pioneer Research Center for Mathematical and Computational Sciences at the Institute for Basic Science. His research focuses on mathematical biology and medicine, specifically the combination of nonlinear dynamics, the theory of stochastic processes, and computational science, to better understand disease mechanisms and develop relevant treatment strategies, including drug and digital medicine for sleep disorders.[3] [4]

Education

Kim was born in Daegu, South Korea in 1982. He attended Yeungnam Middle School and Yeungnam High School before moving to Seoul where he graduated summa cum laude with a B.A. in mathematics education from Seoul National University in 2005. Upon reading a news article about using math to study heart disease, it lead him to the University of Michigan as it was known for mathematical biology.[5] He received his Ph.D. in applied and interdisciplinary mathematics in 2013. He received the Sumner Byron Myers Prize for this thesis on cellular clocks.[6] [7] His advisors were Daniel Forger and Victoria Booth while Trachette Jackson was a thesis committee member.

Career

Kim was a postdoctoral fellow at the Mathematical Biosciences Institute within Ohio State University.[8] [9] [10] Returning to Korea, he served as an assistant[11] and associate professor in the Department of Mathematical Science in KAIST.[12] He also worked as an associate member at the Korea Institute for Advanced Study from 2018 and then as a visiting scholar in the Department of Mathematics in the University of Michigan from 2019 to 2020. He became a member of Young Korean Academy of Science and Technology in 2019.

In March 2021, Kim became a chief investigator of the Pioneer Research Center for Mathematical and Computational Sciences at the Institute for Basic Science (IBS), heading the Biomedical Mathematics Group (BIMAG).[13] [14] [15] Three teams conduct research at BIMAG. The Intracellular Dynamics Team develops reduction methods for multi-scale stochastic systems and identifies molecular mechanisms underlying robust circadian rhythms. The Intercellular Dynamics Team develops inference methods for dynamic networks and causes of and treatment strategies for circadian rhythm sleep disorders at the network level. The Systemic Dynamics Team develops methods for analyzing noisy human activity data from wearable devices and their application to identify optimal sleep patterns, and develops chronotherapy for sleep disorders and cancer.[16]

Mechanisms for period regulation of circadian clock

Despite temperature changes, Kim found a mathematical model which underlies a molecular mechanism for regulation of the circadian clock. This biological clock was discovered in 1954, but the method for how it operates took more than 60 years to understand. Relevant factors include the topology of biochemical network underlying the circadian clock, phospho-switch that controls stability of key repressor proteins can compensate the effects of temperature, cells in the mammalian circadian clocks are coupled to generate synchronized rhythms, and a mechanism that filters stochasticity in the circadian clock.[17] [18]

Mathematical models to treat diseases caused by disrupted circadian rhythms

Misalignment of circadian rhythms with the external environment can cause significant physiological problems. Kim studied the drug PF-670462 which aims to realign the circadian clock. Using pharmacokinetic data, he built a pharmacology model and analyzed the phase response curve to the drug and light which helped to predict the drug's effect under various environmental conditions.[19] As disruption of circadian rhythms increases the risk of getting cancer, he studied the interactions between p53 and PER2.[20]

Derivation of validity condition for stochastic QSSA

Kim was the first to propose and then prove multiple results in justifying the stochastic quasi-steady state approximation (QSSA).[21] [22] [23] [24] [25] The approximation has been widely used to reduce stochastic model of various biological systems.[26] Despite its common use, there has been a critical problem in understanding whether the stochastic QSSA is accurate and under what conditions it may fail. Kim has worked to developing a method to compute the error of the stochastic QSSA directly. This provided a clear guideline for when and how to use the stochastic QSSA. Furthermore, he developed a new method for simplifying models when the stochastic QSSA is invalid.[27] [25]

Discovering and correcting the error in the equation of FDA guidelines

Kim found errors in the US Food and Drug Administration's (FDA) current guidance for predicting how drugs interact in the body and created a more accurate formula. The current FDA method is inaccurate, requiring artificial adjustments. The new formula is based on an improved mathematical foundation and can accurately predict drug metabolism rates without artificial factors. When tested, the new formula predicted drug interactions accurately 80% of the time compared to 38% with the equation in FDA guidance. This improvement could greatly enhance drug development and safety in clinical use.[28] [29] [30]

Software development

BIMAG has also made various software during their research, including mathematical models for biological oscillators, Bayesian inference algorithms, stochastic analysis, causality inference, diagnosis for sleep disorders, and sleep data imputation.[31]

Journal editing

Jae Kyoung has been an editorial board member of Journal of Biological Rhythms,[32] PLOS One,[33] Journal of Theoretical Biology,[34] Mathematical Biosciences,[35] Current Opinion in Systems Biology,[36] npj Systems Biology and Applications,[37] and npj Biological Timing and Sleep,[38] as well as a guest associate editor of PLOS Computational Biology.[39]

Awards and honors

Scientific societies and committees

Selected publications

See also

External links

Notes and References

  1. Web site: 김재경: KAIST 수리과학과 부교수 . . Horizon . . 11 January 2024 . Korean.
  2. Web site: 고등과학원 허준이 수학난제연구소 대중강연 시리즈 . . . 11 January 2024 . Korean.
  3. Web site: A New IBS Center in Mathematical Biology Kicks Off . . 11 March 2021 . . 19 March 2021 .
  4. Web site: iTHEMS Biology Seminar by Dr. Jae Kyoung Kim on November 11, 2021 . Gen Kurosawa . 17 November 2021 . Interdisciplinary Theoretical and Mathematical Sciences Program . . 11 January 2024 .
  5. Web site: [주말N수학] 생명의 비밀 파헤치는 수학의 세계 ]. . 10 July 2021 . . 17 January 2024 . Korean.
  6. Web site: Department Awards . . LSA Mathematics . University of Michigan . 29 August 2022 .
  7. Web site: ContinuUM . . 2014 . Department of Mathematics . University of Michigan . 29 September 2022 .
  8. Web site: Weekly Mathematical Biology Seminar . . 2015 . Department of Mathematics . University of Utah . 29 August 2022 .
  9. Web site: Biomathematics Seminar . . Department of Mathematics . Florida State University . 29 August 2022 .
  10. Web site: Daniel B. Forger III . . University of Michigan . 29 August 2022 .
  11. Web site: KAIST's mathematician reveals the mechanism for sustaining biological rhythms . . 28 August 2015 . . 11 January 2024 .
  12. Web site: 김재경 교수, 올해의 최석정상 수상. . 30 November 2021 . Department of Mathematical Sciences . . 11 January 2024 . Korean.
  13. Web site: IBS 수리·계산과학연구단 의생명 수학 그룹 출범 . 최소라 . 26 February 2021 . YTN Science . . 19 March 2021 . Korean.
  14. Web site: 생물학 난제 수학적 관점에서 푼다…IBS 신규연구그룹 출범 . 고재원 . 26 February 2021 . . 17 January 2024 . Korean.
  15. Web site: 수리생물학으로 수면질환 치료법 찾는다…IBS '의생명 수학그룹' 출범 . . 26 February 2021 . . 17 January 2024 . Korean.
  16. Web site: Research Aim . . IBS Biomedical Mathematics Group . . 11 January 2024 .
  17. Web site: Korean researcher solves 60-year-old puzzle of biological clock through math . . 6 October 2015 . . 17 January 2024 .
  18. Web site: Professor Jae Kyoung Kim Receives the 2017 HSFP Award . . 21 July 2017 . . 30 November 2023 .
  19. Web site: Professor Jae Kyoung Kim to Lead a New Mathematical Biology Research Group at IBS . . 18 March 2021 . News . . 17 January 2024 .
  20. Gotoh . Tetsuya . Kim . Jae Kyoung . Liu . Jingjing . Finkielstein . Carla V. . 9 November 2016 . Model-driven experimental approach reveals the complex regulatory distribution of p53 by the circadian factor Period 2 . . 113. 47. 3516–13521 . 10.1073/pnas.1607984113. free . 27834218 . 5127372 . 2016PNAS..11313516G .
  21. Kim . Jae Kyoung . Josic. Kresimir . Bennett . Matthew R. . 5 August 2014 . The Validity of Quasi-Steady-State Approximations in Discrete Stochastic Simulations . Biophysical Journal . 107 . 3. 783–793 . 10.1016/j.bpj.2014.06.012. 25099817 . 1406.2244 . 2014BpJ...107..783K .
  22. Kim . Jae Kyoung . Josić . Krešimir . Bennett . Matthew R. . 23 November 2015 . The relationship between stochastic and deterministic quasi-steady state approximations . BMC Systems Biology . 9 . 87 . 10.1186/s12918-015-0218-3. free . 26597159 . 4657384 .
  23. Kim. Jae Kyoung . Rempala . Grzegorz . Kang. Hye-Won . Grzegorz Rempala . 12 October 2017 . Reduction for Stochastic Biochemical Reaction Networks with Multiscale Conservations . Multiscale Modeling & Simulation . 15 . 4 . 1376–1403 . 10.1137/16M1099443 . 1704.05628 . 7497139 .
  24. Kim . Jae Kyoung . Sontag . Eduardo D. . Eduardo D. Sontag . 5 June 2017 . Reduction of multiscale stochastic biochemical reaction networks using exact moment derivation. PLOS Computational Biology . 13 . 6 . e1005571 . 10.1371/journal.pcbi.1005571. free . 28582397 . 2017PLSCB..13E5571K .
  25. Song . Yun Min . Hong . Hyukpyo . Kim . Jae Kyoung . 18 October 2018 . Universally valid reduction of multiscale stochastic biochemical systems using simple non-elementary propensities . . 17. 10. e1008952. 10.1371/journal.pcbi.1008952 . free . 34662330 . 8562860 .
  26. Web site: An Estimation Method for Enzyme Kinetic Model Parameters Based on Bayesian Approach . . 31 July 2018 . JSM 2018 . . 6 February 2024 .
  27. Web site: The relationship between deterministic and stochastic quasi-steady-state approximations. . . . 6 February 2024 .
  28. Web site: Scientists re-writes FDA-recommended equation to improve estimation of drug-drug interaction . . 18 January 2023 . . 29 January 2024 .
  29. Web site: [헤럴드광장] 수학이 생명에 필요한 순간 ]. Kim Jae Kyoung . 11 January 2023 . . 29 January 2024 . Korean.
  30. Web site: "美 FDA보다 더 정확" 韓 연구진, 약물 상호작용 예측 수식 개발 . . 4 January 2023 . 헤럴드경제 . 6 February 2024 . Korean.
  31. Web site: Software . . IBS Biomedical Mathematics Group . . 11 January 2024 .
  32. Web site: Editorial Board . . 28 October 2015. . SAGE Publishing . 29 August 2022 .
  33. Web site: Editorial Board . . . 29 August 2022 .
  34. Web site: Editorial board . . . . 11 January 2024 .
  35. Web site: Editorial board . . . . 11 January 2024 . Korean.
  36. Web site: Editorial board . . . 11 January 2024 . Korean.
  37. Web site: About the Editors . . npj Systems Biology and Applications . 6 February 2024 .
  38. Web site: About the Editors . . npj Biological Timing and Sleep . 6 February 2024 .
  39. PLOS Computational Biology . PLOS Computational Biology 2014 Reviewer Thank You . . 27 February 2015 . 29 September 2022 . 10.1371/journal.pcbi.1004184.s001 . free .
  40. Web site: CI Jae Kyoung Kim received the Citation from the Minster Ministry of Science and ICT. CI 김재경 교수님께서 과학기술정보통신부 장관으로부터 표창을 받았습니다 . . 1 November 2023 . IBS Biomedical Mathematics Group . . 11 January 2024 .
  41. Web site: 김재경 교수, 과학기술정보통신부 장관 표창 받아 . . 1 November 2023 . Department of Mathematical Sciences . . 11 January 2024 . Korean.
  42. Web site: 김재경 교수, KAIST 글로벌 연구 협력상 수상해 . . 12 December 2023 . Depatment of Mathematical Sciences . . 11 January 2024 . Korean.
  43. Web site: '2021 최석정상' 수상자 김재경·임선희·송홍엽 교수…수학계 기여 . 이진영 . 25 November 2021 . . 29 September 2022 .
  44. Kim Jae Kyoung . 26 November 2021 . '올해의 최석정상' 김재경·임선희·송홍엽 씨 선정 / YTN 사이언스 . News . Korean . 29 September 2022 . .
  45. Web site: CI Jae Kyoung Kim won '올해의 최석정상.' Congratulation! . . Biomedical Mathematics Group . . 29 September 2022 . ‘올해의 최석정상’ (Choi Seok-jeong award in this year) is named after Choi, Seok-jeong who was a Korean politician and mathematician in the Joseon period of Korea. This award was established 2021 to give mathematicians credit for developing and applying mathematics or spreading mathematics culture..
  46. Web site: 2021년 올해의 최석정상, 한국과학기술원 김재경 교수, 서울대학교 임선희 교수, 연세대학교 송홍엽 교수 선정 . . 29 November 2021 . . 7 October 2022 . Korean.
  47. Web site: J. Shelton Horsley Research Award Past Recipients . . . 29 September 2022 .
  48. Web site: Professor Jae Kyoung Kim Receives the 2017 Human Frontier Science Program Award . . 10 June 2017 . Department of Mathematical Sciences . . 11 January 2024 . Korean.
  49. Web site: Professor Jae-Kyoung Kim Is Named as the Young Researcher of the Year by the Korean Society for Industrial and Applied Mathematics . . 8 November 2017 . Mathematical Sciences . KAIST . 29 September 2022 .
  50. Web site: 수상 . . Korean Society for Industrial and Applied Mathematics . 7 October 2022 . Korean.
  51. Web site: 김재경 교수, 노벨상 펀드 지원 대상자 선정 . . 22 March 2017 . . 29 September 2022 . Korean.
  52. Web site: Teaching . . Dept. of Mathematical Sciences . . 29 September 2022 .
  53. Web site: 이 젊은 과학자들, 대한민국의 미래를 연다 . 유덕영 . 24 November 2016 . . 7 October 2022 . Korean.
  54. Web site: 포스코청암재단, 청암 사이언스(Science) 펠로 31명에게 증서 수여 . . 18 September 2015 . POSCO Newsroom . . 11 January 2024 . Korean.
  55. Web site: 올해의 펠로 . 29 September 2022 . https://www.postf.org/ko/scien/fellow/fellowView.do?fnSeq=1101 . dead . . POSCO TJ Park Foundation . 29 September 2022 . Korean.
  56. Web site: 김재경 교수, 2015년도 대한수학회 상산젊은수학자상 수상 . . 3 November 2015 . Department of Mathematical Sciences . 29 September 2022 . Korean.
  57. Web site: 역대 학회상 수상자. . . 29 September 2022 . Korean.
  58. Web site: Department Awards . . Department of Mathematics . . 29 September 2022 .
  59. Web site: Rackham Awards . . LSA Mathematics . University of Michigan . 7 October 2022 .
  60. Web site: Committees . . Society for Research on Biological Rhythms . 29 September 2022 .
  61. Web site: Conference Information . . SMB2021 . . 29 September 2022 .
  62. Web site: 회원소개. . 11 October 2022 . Korean.
  63. Web site: 국제교류위원회 . . 한국산업응용수학회 . 7 October 2022 . Korean.
  64. Web site: Steering Committee . . Population Approach Group in Korea . 7 October 2022 . Korean.
  65. Web site: 2021-2022 KSIAM 이사회 . . 한국산업응용수학회 . 7 October 2022 . Korean.

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