| Official Name: | Khukhan |
| Native Name: | ขุขันธ์ |
| Native Name Lang: | th |
| Settlement Type: | Amphoe |
| Subdivision Type: | Country |
| Subdivision Name: | Thailand |
| Subdivision Type1: | Province |
| Subdivision Name1: | Sisaket |
| Subdivision Type2: | Seat |
| Subdivision Type3: | Tambon |
| Subdivision Type4: | Muban |
| Established Title: | Amphoe established |
| Population Total: | 148,066 |
| Population As Of: | 2010 |
| Blank Name Sec1: | Postal code |
| Blank Info Sec1: | 33140 |
| Blank Name Sec2: | Geocode |
| Blank Info Sec2: | 3305 |
| Timezone: | ICT |
| Utc Offset: | +7 |
| Coordinates: | 14.7133°N 104.1983°W |
Khukhan (Thai: ขุขันธ์, in Thai pronounced as /kʰùʔ.kʰǎn/) is a district (Amphoe) of Sisaket province, northeastern Thailand.
Neighboring districts are (clockwise, from the north) Prang Ku, Wang Hin, Phrai Bueng, Khun Han, and Phu Sing of Sisaket Province, and Buachet, Sangkha, and Si Narong of Surin Province.
Prior to the re-organization of Thailand for administrative and logistical reasons circa 1945, Khukhan was the provincial capital and is still recognized as the historical center of Sisaket. The reorganization may have been justified in order to connect all the provincial capitals of the lower northeast by the rail line that runs east-west between Korat and Ubon. Khukhan is 48 kilometres south of that line.)
Today, Khukhan is the second most populous district in the province and has numerous roads connecting it to all parts of the province dating back to its earlier importance as the provincial capital. Several temples (wat, วัด) date to the earliest introduction of Buddhism in the area. According to local legend, a battle was fought north of the city which prompted the founding of Khukhan by royal decree.
The district is divided into 22 sub-districts (tambon), further subdivided into 279 villages (muban). Mueang Khukhan is a sub-district municipality (thesaban tambon) which covers parts of the sub-district Huai Nuea. There are 22 Tambon administrative organizations (TAO).
| No. | Name | Thai name | Villages | Pop. | ||
|---|---|---|---|---|---|---|
| 1. | Kanthararom | กันทรารมย์ | 14 | 6,842 | ||
| 2. | Chakong | จะกง | 13 | 6,209 | ||
| 3. | Chai Di | ใจดี | 11 | 6,363 | ||
| 4. | Dong Kam Met | ดองกำเม็ด | 11 | 7,179 | ||
| 5. | Sano | โสน | 22 | 14,562 | ||
| 6. | Prue Yai | ปรือใหญ่ | 20 | 11,506 | ||
| 7. | Sadao Yai | สะเดาใหญ่ | 17 | 6,742 | ||
| 8. | Ta Ut | ตาอุด | 9 | 5,142 | ||
| 9. | Huai Nuea | ห้วยเหนือ | 14 | 12,151 | ||
| 10. | Huai Tai | ห้วยใต้ | 13 | 6,689 | ||
| 11. | Hua Suea | หัวเสือ | 14 | 6,695 | ||
| 13. | Takhian | ตะเคียน | 12 | 5,843 | ||
| 15. | Nikhom Phatthana | นิคมพัฒนา | 11 | 4,272 | ||
| 17. | Khok Phet | โคกเพชร | 11 | 5,532 | ||
| 18. | Prasat | ปราสาท | 9 | 5,956 | ||
| 21. | Samrong Ta Chen | สำโรงตาเจ็น | 17 | 6,122 | ||
| 22. | Huai Samran | ห้วยสำราญ | 11 | 5,388 | ||
| 24. | Kritsana | กฤษณา | 13 | 5,946 | ||
| 25. | Lom Sak | ลมศักดิ์ | 11 | 5,683 | ||
| 26. | Nong Chalong | หนองฉลอง | 10 | 4,017 | ||
| 27. | Si Trakun | ศรีตระกูล | 7 | 3,374 | ||
| 28. | Si Sa-at | ศรีสะอาด | 9 | 4,193 |