| Khlong Nakha Wildlife Sanctuary | |
| Iucn Category: | IV |
| Map: | Thailand |
| Location: | Thailand |
| Nearest City: | Ranong |
| Coordinates: | 9.4333°N 133°W |
| Area: | 530.3296 km2 |
| Established: | 26 May 1972 |
| Governing Body: | Wildlife Conservation Office |
Khlong Nakha (Thai: คลองนาคา) is a wildlife sanctuary in southern Thailand, located in the southeast of Ranong Province. It is located within the hills of the Phuket mountain range.
It covers an area of 530 km2, covering area of the tambon Chiao Liang, Ban Na and Bang Hin of Kapoe district, Nakha and Kam Phuan of Suk Samran, as well as tambon Khao Pang of Ban Ta Khun of Surat Thani Province.
The wildlife reserve was established in 1972, originally covering an area of 480 km2. In 1991 50 km2 of tambon Khao Pang were added to the reserve.