| Khanyisa Mayo | |
| Birth Date: | 1998 8, df=yes |
| Birth Place: | Mthatha, South Africa |
| Height: | 1.78m |
| Position: | Forward |
| Currentclub: | CR Belouizdad |
| Years1: | 2017–2018 |
| Caps1: | 0 |
| Goals1: | 0 |
| Years2: | 2017–2018 |
| Clubs2: | →Ubuntu Cape Town (loan) |
| Caps2: | 8 |
| Goals2: | 2 |
| Years3: | 2018–2019 |
| Clubs3: | Maccabi |
| Caps3: | 1 |
| Goals3: | 0 |
| Years4: | 2019–2020 |
| Clubs4: | Royal Eagles |
| Caps4: | 15 |
| Goals4: | 3 |
| Years5: | 2020–2021 |
| Clubs5: | Richards Bay |
| Caps5: | 36 |
| Goals5: | 11 |
| Years6: | 2021–2024 |
| Caps6: | 50 |
| Goals6: | 16 |
| Years7: | 2024– |
| Caps7: | 0 |
| Goals7: | 0 |
| Nationalyears1: | 2015 |
| Nationalteam1: | South Africa U17 |
| Nationalcaps1: | 18 |
| Nationalgoals1: | 6 |
| Nationalyears2: | 2017 |
| Nationalteam2: | South Africa U20 |
| Nationalcaps2: | 1 |
| Nationalgoals2: | 0 |
| Nationalyears3: | 2022– |
| Nationalteam3: | South Africa |
| Nationalcaps3: | 4 |
| Nationalgoals3: | 0 |
| Pcupdate: | 3 August 2024 |
| Ntupdate: | 3 August 2024 |
Khanyisa Mayo (born 27 August 1998) is a South African professional soccer player who plays as a forward for CR Belouizdad and the South Africa national team.
Mayo began his senior career in 2017 on loan with Ubuntu Cape Town in the National First Division, from SuperSport United. He transferred to Maccabi in 2018 where he made a solitary appearance that season. He followed that up with a stint at Royal Eagles in the first half of the 2019–20 season, and for the second half he moved to Richards Bay.[1] He earned a move to South African Premier Division side Cape Town City on 28 July 2021.[2]
Mayo was called up to the South Africa national team for a set of friendlies in September 2022. He made his debut with them in a 4–0 friendly win over Sierra Leone on 24 September 2022.[3]
Mayo is the son of the former South African international footballer Patrick Mayo.[4]