| Official Name: | Khaneh Khamis-e Sofla |
| Native Name: | خانه خميس سفلي |
| Settlement Type: | village |
| Pushpin Map: | Iran |
| Mapsize: | 150px |
| Subdivision Type: | Country |
| Subdivision Type1: | Province |
| Subdivision Name1: | Fars |
| Subdivision Type2: | County |
| Subdivision Name2: | Shiraz |
| Subdivision Type3: | Bakhsh |
| Subdivision Name3: | Central |
| Subdivision Type4: | Rural District |
| Subdivision Name4: | Siyakh Darengun |
| Population As Of: | 2006 |
| Population Total: | 713 |
| Population Density Km2: | auto |
| Timezone: | IRST |
| Utc Offset: | +3:30 |
| Timezone Dst: | IRDT |
| Utc Offset Dst: | +4:30 |
| Coordinates: | 29.5261°N 52.3044°W |
Khaneh Khamis-e Sofla (Persian: خانه خميس سفلي, also Romanized as Khāneh Khamīs-e Soflá; also known as Khānkhamīs-e Soflá) is a village in Siyakh Darengun Rural District, in the Central District of Shiraz County, Fars Province, Iran. At the 2006 census, its population was 713, in 144 families.