| Official Name: | Kham Thale So |
| Native Name: | ขามทะเลสอ |
| Native Name Lang: | th |
| Settlement Type: | District |
| Subdivision Type: | Country |
| Subdivision Name: | Thailand |
| Subdivision Type1: | Province |
| Subdivision Name1: | Nakhon Ratchasima |
| Subdivision Type2: | Seat |
| Subdivision Name2: | Kham Thale So |
| Subdivision Type3: | Subdistrict |
| Subdivision Type4: | Muban |
| Established Title: | District established |
| Population Total: | 28306 |
| Population As Of: | 2000 |
| Blank Name Sec1: | Postal code |
| Blank Info Sec1: | 30280 |
| Blank Name Sec2: | Geocode |
| Blank Info Sec2: | 3019 |
| Timezone: | ICT |
| Utc Offset: | +7 |
| Coordinates: | 14.9608°N 101.9475°W |
Kham Thale So (in Thai pronounced as /kʰǎːm tʰā.lēː sɔ̌ː/) is a district (amphoe) of Nakhon Ratchasima province, northeastern Thailand.
The government separated some parts of Non Thai and Sung Noen districts and created the minor district (king amphoe) Kham Thale So in 1958, which was upgraded to a full district in 1965.
Neighbouring districts are (from the north clockwise) Non Thai, Mueang Nakhon Ratchasima, Sung Noen, and Dan Khun Thot.
The district is divided into five sub-districts (tambons). Kham Thale So is also a township (thesaban tambon) which covers parts of the tambon Kham Thale So.
| 1. | Kham Thale So | ขามทะเลสอ | ||
| 2. | Pong Daeng | โป่งแดง | ||
| 3. | Phan Dung | พันดุง | ||
| 4. | Nong Suang | หนองสรวง | ||
| 5. | Bueng O | บึงอ้อ |
The district is the site of salt mines operated by the Saltworks Company, a major producer of salt for the chemical and food industries.[1]