Ketorfanol Explained

Ketorfanol (INN, USAN) (developmental code name SBW-22), or ketorphanol, is an opioid analgesic of the morphinan family that was found to possess "potent antiwrithing activity" in animal assays but was never marketed.^{[1] [2]} It is a 17-cycloalkylmethyl derivative of morphinan and as such, is closely related structurally to butorphanol, cyclorphan, oxilorphan, proxorphan, and xorphanol, which act preferentially as κ-opioid receptor agonists and to a lesser extent as μ-opioid receptor partial agonists/antagonists.^[3]

See also

• Butorphanol
• Levallorphan
• Levomethorphan
• Levorphanol
• Nalbuphine
• Xorphanol

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies . 14 November 2014 . Springer . 978-1-4757-2085-3 . 720–.
2. Book: Korolkovas, Andrejus . vanc . Essentials of Medicinal Chemistry . 16 August 1988 . Wiley . 978-0-471-88356-2 . 243.
3. Neumeyer JL, Bidlack JM, Zong R, Bakthavachalam V, Gao P, Cohen DJ, Negus SS, Mello NK . 6 . Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine dependence . Journal of Medicinal Chemistry . 43 . 1 . 114–22 . January 2000 . 10633042 . 10.1021/jm9903343 .