Ketofol Explained

Ketofol is a mixture of ketamine and propofol. Both drugs are anesthetic agents. It can be mixed with propofol in the same syringe.^[1]

The combination appears to be safer than propofol by itself when used for procedural sedation and analgesia.^[2]

Notes and References

1. Willman EV, Andolfatto G . A prospective evaluation of "ketofol" (ketamine/propofol combination) for procedural sedation and analgesia in the emergency department . Annals of Emergency Medicine . 49 . 1 . 23–30 . January 2007 . 17059854 . 10.1016/j.annemergmed.2006.08.002 .
2. Jalili M, Bahreini M, Doosti-Irani A, Masoomi R, Arbab M, Mirfazaelian H . Ketamine-propofol combination (ketofol) vs propofol for procedural sedation and analgesia: systematic review and meta-analysis . The American Journal of Emergency Medicine . 34 . 3 . 558–69 . March 2016 . 26809929 . 10.1016/j.ajem.2015.12.074 .