Ketipramine Explained

Ketipramine (G-35,259), also known as ketimipramine or ketoimipramine, is a tricyclic antidepressant (TCA) that was tested in clinical trials for the treatment of depression in the 1960s but was never marketed.^{[1] [2] [3]} It differs from imipramine in terms of chemical structure only by the addition of a ketone group, to the azepine ring, and is approximately equivalent in effectiveness as an antidepressant in comparison.^[4]

It was one of the drugs prescribed by Roland Kuhn in a series of unethical experiments to test drugs on children without informed consent and without proper approval at the psychiatric hospital in Münsterlingen, Switzerland.^{[5] [6] [7]}

See also

• Tricyclic antidepressant

Notes and References

1. Book: Dictionary of organic compounds . Chapman & Hall . London . 1996 . 0-412-54090-8 .
2. Simeon J, Fuchs M, Nikolovski O, Bucci L . Ketipramine in the therapy of depression in outpatients . Psychosomatics . 11 . 4 . 342–6 . 1970 . 5459338 . 10.1016/S0033-3182(70)71634-4 . https://archive.today/20110727193210/http://psy.psychiatryonline.org/cgi/pmidlookup?view=long&pmid=5459338 . dead . 2011-07-27 .
3. Park S, Glick B, Floyd A, Gershon S . Ketipramine fumarate as compared to imipramine in depressed outpatients . Current Therapeutic Research, Clinical and Experimental . 13 . 5 . 322–5 . May 1971 . 4998396 .
4. Book: Author Unknown . Ann Reports Medicinal Chem V6 (v. 6) . Academic Press . Boston . 1971 . 0-12-040506-7 .
5. https://www.tagesanzeiger.ch/schweiz/standard/die-experimente-von-muensterlingen/story/23214536 Die Experimente von Münsterlingen
6. https://web.archive.org/web/20161101000721/http://www.thurgauerzeitung.ch/nachrichten/schweiz/schweiz-sda/Mehr-Medikamentenversuche-in-Muensterlingen;art253650,4806950 Münsterlingen: Alles noch viel schlimmer
7. Simone Rau: Das Ausmass der Medi-Versuche in Münsterlingen ist weit grösser. In: Der Bund, 31. Oktober 2016.