Keratinocyte growth factor explained

The keratinocyte growth factor (KGF), also known as FGF7, is a growth factor present in the epithelialization-phase of wound healing. In this phase, keratinocytes are covering the wound, forming the epithelium.

KGF is a small signaling molecule that binds to fibroblast growth factor receptor 2b (FGFR2b).^[1] For signalling to occur, a dimer is required between two FGF:FGFR complexes that is linked together by a molecule of heparin.

There are 23 known FGFs, and 4 FGF receptors. FGF:FGFR binding is complex and regulated by a variety of mechanisms in a tissue specific manner.

FGF10 is also known as "keratinocyte growth factor 2".^[2]

See also

• Palifermin

External links

• FGF 2-FGFR 1c-Heparin (2:2:2) Complex

Notes and References

1. Rotolo S, Ceccarelli S, Romano F, Frati L, Marchese C, Angeloni A . Silencing of Keratinocyte Growth Factor Receptor Restores 5-Fluorouracil and Tamoxifen Efficacy on Responsive Cancer Cells . PLOS ONE . 3 . 6 . e2528 . 2008 . 18575591 . 2424182 . 10.1371/journal.pone.0002528 . Maas . Stefan. 2008PLoSO...3.2528R . free .
2. Web site: iHOP - Information Hyperlinked over Proteins [FGF10 ] ]. https://web.archive.org/web/20120214080411/http://www.ihop-net.org/UniPub/iHOP/gs/88201.html . 2012-02-14 . dead .